425629-94-3
425629-94-3
Chemical Structure
PfDHODH-IN-2
- CAS. Nr.: 425629-94-3
- Formula:C13H12ClNO3S
- Molecular Weight:297.76
IUPAC Name: ethyl 2-((4-chlorophenyl)amino)-4-oxo-4,5-dihydrothiophene-3-carboxylate
InChIKey: KJEPGRNXDUXOLD-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=CC=C(Cl)C=C2)SCC1=O)OCC
Biological Activity: PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1].
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PfDHODH-IN-2 | PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria. | |||||||||||||||||||||
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