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  3. Borrelidin

Borrelidin (Synonyms: Treponemycin)

Cat. No.: HY-N6742 Purity: >98.0%
Handling Instructions

Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei. Borrelidin (Treponemycin) is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM. Borrelidin (Treponemycin) is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM, and induces apoptosis of the tube-forming cells. Borrelidin (Treponemycin) has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum.

For research use only. We do not sell to patients.

Borrelidin Chemical Structure

Borrelidin Chemical Structure

CAS No. : 7184-60-3

Size Price Stock Quantity
500 μg USD 200 In-stock
Estimated Time of Arrival: December 31
1 mg USD 340 In-stock
Estimated Time of Arrival: December 31
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Description

Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin (Treponemycin) is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM[2]. Borrelidin (Treponemycin) is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM, and induces apoptosis of the tube-forming cells. Borrelidin (Treponemycin) has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum[3].

IC50 & Target

IC50:24 μM (Cdc28/Cln2)[2]

In Vitro

Borrelidin (Treponemycin) can target ALL cell lines and induce apoptosis and mediating G(1) arrest.

Molecular Weight

489.64

Formula

C₂₈H₄₃NO₆

CAS No.

7184-60-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 100 mg/mL (204.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0423 mL 10.2116 mL 20.4232 mL
5 mM 0.4085 mL 2.0423 mL 4.0846 mL
10 mM 0.2042 mL 1.0212 mL 2.0423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Borrelidin
Cat. No.:
HY-N6742
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