Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model

  • J Antibiot (Tokyo). 1997 Aug;50(8):671-6. doi: 10.7164/antibiotics.50.671.
T Wakabayashi  1 ,  R Kageyama ,  N Naruse ,  N Tsukahara ,  Y Funahashi ,  K Kitoh ,  Y Watanabe
Affiliations
  • 1. Tsukuba Research Laboratories, Eisai, Co., Ltd., Ibaraki, Japan.
PMID: 9315080 DOI: 10.7164/antibiotics.50.671
Abstract

Borrelidin, an Antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of 0.8 nM, and decreased the number of capillary tubes within 24 hours when added after maturation of tube formation. Borrelidin remarkably disrupted capillary tubes in a dose-dependent manner, by inducing Apoptosis of the tube-forming cells.

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