1. Anti-infection
  2. Parasite
  3. AQ-13 dihydrochloride

AQ-13 dihydrochloride 

Cat. No.: HY-100358 Purity: 98.08%
Handling Instructions

AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.

For research use only. We do not sell to patients.

AQ-13 dihydrochloride Chemical Structure

AQ-13 dihydrochloride Chemical Structure

CAS No. : 169815-40-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.

In Vivo

Slight decreases in the PCE/RBC ratio are observed in male and female rats treated with CQ and in females only treated with AQ-13; however, none of these changes is statistically significant[1].

Clinical Trial
Molecular Weight

364.74

Formula

C₁₆H₂₄Cl₃N₃

CAS No.

169815-40-1

SMILES

CCN(CC)CCCNC1=CC=NC2=CC(Cl)=CC=C12.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 80 mg/mL (219.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7417 mL 13.7084 mL 27.4168 mL
5 mM 0.5483 mL 2.7417 mL 5.4834 mL
10 mM 0.2742 mL 1.3708 mL 2.7417 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.67 mg/mL (7.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.67 mg/mL (7.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.67 mg/mL (7.32 mM); Clear solution; Need warming

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Rats[1]
Male and female Sprague-Dawley rats are used and are 8-9 weeks of age at the time of dose administration. Micronucleus evaluations are conducted in conjunction with repeatdose toxicity studies. Rats are orally administered AQ-13 or CQ in water. Rats are given a “loading dose” followed by maintenance doses of one-half the loading dose administered 12 hr later and daily thereafter for 6 additional days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Product Name:
AQ-13 dihydrochloride
Cat. No.:
HY-100358
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