JMI-346
JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQS (3D7; IC50=13 µM) and CQR (RKL-9; IC50=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent.
For research use only. We do not sell to patients.
- CAS No.: 2091841-46-0
- Formula: C19H20N4O2
- Molecular Weight:336.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
291.56 μM
Compound: 40
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Cytotoxicity against human PMA-differentaited THP1 cells after 24 hrs by MTT assay
Cytotoxicity against human PMA-differentaited THP1 cells after 24 hrs by MTT assay
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[PMID: 28359789] |
Chemical Information
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CAS No. 2091841-46-0
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Molecular Weight 336.39
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Formula C19H20N4O2
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SMILES
N[C@@H](CC1=CC=CC=C1)C(OCC2=CN(C3=CC=C(C)C=C3)N=N2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JMI-346 Related Classifications
HY-147850 Related Classifications
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