2091841-46-0
2091841-46-0
Chemical Structure
JMI-346
- CAS No.: 2091841-46-0
- Formula:C19H20N4O2
- Molecular Weight:336.39
IUPAC Name: (1-(p-tolyl)-1H-1,2,3-triazol-4-yl)methyl L-phenylalaninate
InChIKey: TZQPUBNRMQNCDV-SFHVURJKSA-N
SMILES: N[C@@H](CC1=CC=CC=C1)C(OCC2=CN(C3=CC=C(C)C=C3)N=N2)=O
Biological Activity: JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQS (3D7; IC50=13 µM) and CQR (RKL-9; IC50=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent[1].
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JMI-346 | JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQS (3D7; IC50=13 µM) and CQR (RKL-9; IC50=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent. | |||||||||||||||||||||
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