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Cat. No.: HY-160633

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PfFAS-II inhibitor 1

PfFAS-II inhibitor 1 (Compound 3) is a Plasmodium falciparum type II fatty acid biosynthesis pathway (PfFAS-II) inhibitor, with an IC₅₀ of 0.63 μM for PfFabI enzyme. PfFAS-II inhibitor 1 has antimalarial activity.

For research use only. We do not sell to patients.

CAS No.: 1459704-68-7
Formula: C₁₅H₉ClO₄
Molecular Weight:288.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PfFAS-II inhibitor 1 Chemical Structure

CAS No.: 1459704-68-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

Plasmodium falciparum Type II Fatty Acid Biosynthesis Pathway (PfFAS-II)^[1]

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
L6	IC₅₀	96.2 μM Compound: 3	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis	[PMID: 24063369]

Chemical Information

CAS No. 1459704-68-7
Molecular Weight 288.68
Formula C₁₅H₉ClO₄
SMILES

O=C1OC2=C(C=C1)C=C(OC3=CC=C(C=C3O)Cl)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Belluti F, et al. Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). J Med Chem. 2013 Oct 10;56(19):7516-26. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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