1. Anti-infection
  2. Parasite
  3. Ganaplacide hydrochloride

Ganaplacide hydrochloride (Synonyms: KAF156 hydrochloride; GNF156 hydrochloride)

Cat. No.: HY-108024A Purity: ≥98.0%
Handling Instructions

Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite.

For research use only. We do not sell to patients.

Ganaplacide hydrochloride Chemical Structure

Ganaplacide hydrochloride Chemical Structure

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 638 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 638 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg USD 880 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite[1][2].

In Vitro

Ganaplacide (KAF156) hydrochloride shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM against P. falciparum drug-sensitive and drug-resistant strains[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KAF156 displays cidal activity against mature Plasmodium falciparum gametocytes and thus blocks parasite transmission to Anopheles mosquitoes[1].
Ganaplacide (KAF156) hydrochloride (1-15 mg/kg; p.o.) is fully protective in a causal prophylactic mouse model of malaria[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (causal prophylactic rodent malaria model)[1]
Dosage: 1-15 mg/kg
Administration: P.o.
Result: A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
Clinical Trial
Molecular Weight

447.91

Formula

C₂₂H₂₄ClF₂N₅O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (223.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2326 mL 11.1630 mL 22.3259 mL
5 mM 0.4465 mL 2.2326 mL 4.4652 mL
10 mM 0.2233 mL 1.1163 mL 2.2326 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Product Name:
Ganaplacide hydrochloride
Cat. No.:
HY-108024A
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