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  3. Ganaplacide hydrochloride

Ganaplacide hydrochloride (Synonyms: KAF156 hydrochloride; GNF156 hydrochloride)

Cat. No.: HY-108024A
Handling Instructions

Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite.

For research use only. We do not sell to patients.

Ganaplacide hydrochloride Chemical Structure

Ganaplacide hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg USD 880 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 Get quote
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite[1][2].

In Vitro

Ganaplacide (KAF156) hydrochloride shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM against P. falciparum drug-sensitive and drug-resistant strains[1].

In Vivo

KAF156 displays cidal activity against mature Plasmodium falciparum gametocytes and thus blocks parasite transmission to Anopheles mosquitoes[1].
Ganaplacide (KAF156) hydrochloride (1-15 mg/kg; p.o.) is fully protective in a causal prophylactic mouse model of malaria[1].

Animal Model: Mice (causal prophylactic rodent malaria model)[1]
Dosage: 1-15 mg/kg
Administration: P.o.
Result: A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
Molecular Weight

447.91

Formula

C₂₂H₂₄ClF₂N₅O

SMILES

FC(C=C1)=CC=C1C2=C(N3C(C(C)(N(C(CN)=O)CC3)C)=N2)NC4=CC=C(F)C=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

GanaplacideKAF156GNF156KAF 156KAF-156GNF 156GNF-156Parasitefirst-in-classoralprophylacticcausaltransmissiongametocyteInhibitorinhibitorinhibit

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Product Name:
Ganaplacide hydrochloride
Cat. No.:
HY-108024A
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