1. Anti-infection
    Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Parasite
    Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
  3. DHODH-IN-8

DHODH-IN-8 

Cat. No.: HY-135666
Handling Instructions

DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity.

For research use only. We do not sell to patients.

DHODH-IN-8 Chemical Structure

DHODH-IN-8 Chemical Structure

CAS No. : 1148126-03-7

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Description

DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity[1].

IC50 & Target

IC50: 0.13 μM (human DHODH) and 47.4 μM (Plasmodium falciparum DHODH)[1]
Ki: 0.016 μM (human DHODH) and 5.6 μM (Plasmodium falciparum DHODH)[1]

In Vitro

The dihydroorotate dehydrogenases (DHODHs) are attractive chemotherapeutic targets in various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and for the treatment of human disease. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by utilizing an FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. The human DHODH (HsDHODH)a and the P. falciparum DHODH (PfDHODH) both belong to the group of class 2 DHODHs that use respiratory quinones as the terminal electron acceptors[1].

Molecular Weight

312.75

Formula

C₁₇H₁₃ClN₂O₂

CAS No.

1148126-03-7

SMILES

C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2Cl)C=C1)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DHODH-IN-8ParasiteDihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHPlasmodiumfalciparumantimalarialHsDHODHPfDHODHInhibitorinhibitorinhibit

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