1148126-03-7
1148126-03-7
Chemical Structure
DHODH-IN-8
- CAS No.: 1148126-03-7
- Formula:C17H13ClN2O2
- Molecular Weight:312.75
IUPAC Name: (Z)-N-(2'-chloro-[1,1'-biphenyl]-4-yl)-2-cyano-3-hydroxybut-2-enamide
InChIKey: LPTUTTULCBOUPL-PTNGSMBKSA-N
SMILES: C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2Cl)C=C1)=O
Biological Activity: DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity[1].
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DHODH-IN-8 | DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity. | |||||||||||||||||||||
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References
Keywords
