1. Anti-infection
  2. Bacterial
    Parasite
    HCV
  3. Micrococcin P1

Micrococcin P1 

Cat. No.: HY-125728
Handling Instructions

Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum.

For research use only. We do not sell to patients.

Micrococcin P1 Chemical Structure

Micrococcin P1 Chemical Structure

CAS No. : 67401-56-3

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Description

Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM[1]. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively[2]. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum[3].

IC50 & Target

HCV[1]; Bacterial[2]; Parasite[3]

In Vitro

Dose-response assays reveales Micrococcin P1 to be very potent with a minimal inhibitory concentration (MIC) of 32-63 nM. Cytotoxicity assays reveales no significant impairment on cell line growth (<10% inhibition at 30 mM) over a 40 h period for both the hepatic cell line HepG2 and the monocytic cell line THP-1, leading to a selectivity index greater than 500. Also investigats the intracellular activity of Micrococcin P1, it is active against GFP-expressing M. tuberculosis H37Rv growing inside RAW 264.7 macrophages with an IC80 of about 1 mM with potency comparable with that of isoniazid[1].

Molecular Weight

1144.37

Formula

C₄₈H₄₉N₁₃O₉S₆

CAS No.

67401-56-3

SMILES

C[[email protected]](C(N1)C2=NC(C3=NC(C4=NC(C5=NC(C(N/C(C(NC[[email protected]](O)C)=O)=C\C)=O)=CS5)=CS4)=CC=C3C6=NC(C(N[[email protected]@](C(N/C(C7=NC(C(N[[email protected]@H](C(C)C)C8=NC(C1=O)=CS8)=O)=CS7)=C\C)=O)([H])[[email protected]](O)C)=O)=CS6)=CS2)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Micrococcin P1Micrococcin P 1Micrococcin P-1BacterialParasiteHCVHepatitis C virusInhibitorinhibitorinhibit

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