67401-56-3
Chemical Structure
Micrococcin P1
- CAS No.: 67401-56-3
- Formula:C48H49N13O9S6
- Molecular Weight:1144.37
IUPAC Name: 2'-((12Z,32Z,72Z,112Z,8S,12Z,15S)-12-ethylidene-4,15-bis((R)-1-hydroxyethyl)-8-isopropyl-6,10,14,17-tetraoxo-5,9,13,16-tetraaza-1(2,4),3,7,11(4,2)-tetrathiazola-2(3,2)-pyridinacycloheptadecaphane-26-yl)-N-((Z)-1-(((R)-2-hydroxypropyl)amino)-1-oxobut-2-en-2-yl)-[2,4'-bithiazole]-4-carboxamide
InChIKey: MQGFYNRGFWXAKA-YGVCRTKKSA-N
SMILES: C[C@H](C(N1)C2=NC(C3=NC(C4=NC(C5=NC(C(N/C(C(NC[C@H](O)C)=O)=C\C)=O)=CS5)=CS4)=CC=C3C6=NC(C(N[C@@](C(N/C(C7=NC(C(N[C@@H](C(C)C)C8=NC(C1=O)=CS8)=O)=CS7)=C\C)=O)([H])[C@H](O)C)=O)=CS6)=CS2)O
Biological Activity: Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM[1]. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively[2]. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Micrococcin P1 | 99.0% | Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum. | ||||||||||||||||||||
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References
- [1]. Lee M, et al. Micrococcin P1, a naturally occurring macrocyclic peptide inhibiting hepatitis C virus entry in a pan-genotypic manner. Antiviral Res. 2016 Aug;132:287-95. [Content Brief]
- [2]. Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst. Chem Sci. 2018 Dec 3;10(7):1971-1975. [Content Brief]
- [3]. Carnio MC, et al. Pyridinyl polythiazole class peptide antibiotic micrococcin P1, secreted by foodborne Staphylococcus equorum WS2733, is biosynthesized nonribosomally. Eur J Biochem. 2001 Dec;268(24):6390-401. [Content Brief]
