1. Anti-infection
    Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Parasite
    Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
  3. DHODH-IN-4

DHODH-IN-4 

Cat. No.: HY-135619
Handling Instructions

DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity.

For research use only. We do not sell to patients.

DHODH-IN-4 Chemical Structure

DHODH-IN-4 Chemical Structure

CAS No. : 1148125-93-2

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Description

DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1].

IC50 & Target

IC50: 4 μM (PfDHODH), 0.18 μM (HsDHODH)[1].

Molecular Weight

347.20

Formula

C₁₇H₁₂Cl₂N₂O₂

CAS No.

1148125-93-2

SMILES

C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2Cl)C=C1Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DHODH-IN-4ParasiteDihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHantimalarialPlasmodium falciparumInhibitorinhibitorinhibit

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