2-Butenoyl coenzyme A lithium
Based on 1 Customer Validation
2-Butenoyl coenzyme A lithium is an inactivator and a substrate of Plasmodium falciparum enoyl-β-hydroxyacyl-acyl carrier protein (ACP) reductase and other enoyl-CoA reductases, and it is also the lithium salt of trans-2-methyl-2-butenoyl coenzyme A. 2-Butenoyl coenzyme A lithium acts on short-chain and medium-chain coenzyme A dehydrogenases as well as glutaryl-CoA dehydrogenase, and shows no activity against wild-type isovaleryl-CoA dehydrogenase. 2-Butenoyl coenzyme A lithium functions as a metabolite in the L-isoleucine catabolic pathway, and can serve as a substrate in the activity assay of 3-ketothiolase. 2-Butenoyl coenzyme A lithium is applicable to research related to 3-ketothiolase deficiency.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 102680-35-3
- Formula: C25H36Li4N7O17P3S
- Molecular Weight:859.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
2-Butenoyl coenzyme A lithium serves as a substrate analog for kinetic studies of β-hydroxyacyl-acyl carrier protein (ACP) dehydratase (FabZ)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 102680-35-3
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Appearance Solid
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Molecular Weight 859.34
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Formula C25H36Li4N7O17P3S
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Color White to off-white
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SMILES
O[C@H]1[C@](O[C@@H]([C@H]1OP(O[Li])(O[Li])=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(/C=C/C)=O)=O)=O)(O[Li])=O)(O[Li])=O)([H])N2C3=NC=NC(N)=C3N=C2
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Schaller RA, et al. Mechanism-based inhibitor discrimination in the acyl-CoA dehydrogenases. Biochemistry. 1997;36(25):7761-7768. [Content Brief]
[2]. Gibson KM, et al. A coupled assay detecting defects in fibroblast isoleucine degradation distal to enoyl-CoA hydratase: application to 3-oxothiolase deficiency. Clin Chim Acta. 1992;205(1-2):127-135. [Content Brief]
[3]. Weizhi Liu, et al. A new beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: Molecular cloning, enzymatic characterization, and structural modeling. Biochem Biophys Res Commun. 2005 Aug 12;333(4):1078-86. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Butenoyl coenzyme A lithium Related Classifications
HY-134421 Related Classifications
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