2-Butenoyl coenzyme A lithium 

2-Butenoyl coenzyme A lithium is an inactivator and a substrate of Plasmodium falciparum enoyl-β-hydroxyacyl-acyl carrier protein (ACP) reductase and other enoyl-CoA reductases, and it is also the lithium salt of trans-2-methyl-2-butenoyl coenzyme A. 2-Butenoyl coenzyme A lithium acts on short-chain and medium-chain coenzyme A dehydrogenases as well as glutaryl-CoA dehydrogenase, and shows no activity against wild-type isovaleryl-CoA dehydrogenase. 2-Butenoyl coenzyme A lithium functions as a metabolite in the L-isoleucine catabolic pathway, and can serve as a substrate in the activity assay of 3-ketothiolase. 2-Butenoyl coenzyme A lithium is applicable to research related to 3-ketothiolase deficiency^[1][2][3].

2-Butenoyl coenzyme A lithium serves as a substrate analog for kinetic studies of β-hydroxyacyl-acyl carrier protein (ACP) dehydratase (FabZ)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₅H₃₆Li₄N₇O₁₇P₃S

102680-35-3

Solid

White to off-white

O[C@H]1[C@](O[C@@H]([C@H]1OP(O[Li])(O[Li])=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(/C=C/C)=O)=O)=O)(O[Li])=O)(O[Li])=O)([H])N2C3=NC=NC(N)=C3N=C2

859.34

Room temperature in continental US; may vary elsewhere.

• [1]. Schaller RA, et al. Mechanism-based inhibitor discrimination in the acyl-CoA dehydrogenases. Biochemistry. 1997;36(25):7761-7768.  [Content Brief]

  [2]. Gibson KM, et al. A coupled assay detecting defects in fibroblast isoleucine degradation distal to enoyl-CoA hydratase: application to 3-oxothiolase deficiency. Clin Chim Acta. 1992;205(1-2):127-135.

  [3]. Weizhi Liu, et al. A new beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: Molecular cloning, enzymatic characterization, and structural modeling. Biochem Biophys Res Commun. 2005 Aug 12;333(4):1078-86.  [Content Brief]