1. Anti-infection
    Apoptosis
  2. Bacterial
    Parasite
    Apoptosis
  3. beta-Mangostin

beta-Mangostin (Synonyms: β-Mangostin)

Cat. No.: HY-N0941 Purity: 99.74%
Handling Instructions

beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).

For research use only. We do not sell to patients.

beta-Mangostin Chemical Structure

beta-Mangostin Chemical Structure

CAS No. : 20931-37-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 277 In-stock
Estimated Time of Arrival: December 31
5 mg USD 252 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic)[1][2][3][4].

In Vitro

beta-Mangostin activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G0/G1 cell-cycle arrest[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

424.49

Formula

C₂₅H₂₈O₆

CAS No.

20931-37-7

SMILES

C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(OC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (588.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3558 mL 11.7788 mL 23.5577 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL
10 mM 0.2356 mL 1.1779 mL 2.3558 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (14.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

beta-Mangostinβ-MangostinBacterialParasiteApoptosisantibacterialantimalarialapoptosisintrinsicpathwaycell-cyclearresthepatocellularcarcinomacellinvasionmigrationleukaemicInhibitorinhibitorinhibit

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beta-Mangostin
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