Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana

  • Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9. doi: 10.1248/cpb.51.857.
Sunit Suksamrarn  1 ,  Narisara Suwannapoch ,  Wong Phakhodee ,  Janthana Thanuhiranlert ,  Piniti Ratananukul ,  Nitirat Chimnoi ,  Apichart Suksamrarn
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand. [email protected]
PMID: 12843596 DOI: 10.1248/cpb.51.857
Abstract

Prenylated Xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated Xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.

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