TCMDC-135051 hydrochloride
Based on 1 Customer Validation
TCMDC-135051 hydrochloride is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC50=320 nM).
For research use only. We do not sell to patients.
- Purity: 98.17%
- CAS No.: 2705545-47-5
- Formula: C29H34ClN3O3
- Molecular Weight:508.05
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Anti-Infection Compound Library
HY-L002
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Antiparasitic Compound library
HY-L082
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Heterocyclic Compound Library
HY-L138
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Highly Selective Inhibitors Library
HY-L158
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
All Parasite Isoforms
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Biological Activity
TCMDC-135051 hydrochloride shows potent activity against P. berghei sporozoites in a liver invasion and development assay in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM). The kinase assays using recombinant PvCLK3 (P. vivax) and PbCLK3 (P. berghei) show that TCMDC-135051 hydrochloride has near-equipotent inhibition at these two orthologs, with pIC50 values of 7.47 (IC50=0.033 μM) and 7.86 (IC50=0.013 μM), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2705545-47-5
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Appearance Solid
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Molecular Weight 508.05
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Formula C29H34ClN3O3
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Color Light yellow to yellow
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SMILES
O=C(O)C1=CC=C(C2=C3C(NC(C4=C(OC)C=CC(CN(CC)CC)=C4)=C3)=NC=C2)C=C1C(C)C.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 83.33 mg/mL (164.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9683 mL | 9.8416 mL | 19.6831 mL | 49.2078 mL |
| 5 mM | 0.3937 mL | 1.9683 mL | 3.9366 mL | 9.8416 mL | |
| 10 mM | 0.1968 mL | 0.9842 mL | 1.9683 mL | 4.9208 mL | |
| 15 mM | 0.1312 mL | 0.6561 mL | 1.3122 mL | 3.2805 mL | |
| 20 mM | 0.0984 mL | 0.4921 mL | 0.9842 mL | 2.4604 mL | |
| 25 mM | 0.0787 mL | 0.3937 mL | 0.7873 mL | 1.9683 mL | |
| 30 mM | 0.0656 mL | 0.3281 mL | 0.6561 mL | 1.6403 mL | |
| 40 mM | 0.0492 mL | 0.2460 mL | 0.4921 mL | 1.2302 mL | |
| 50 mM | 0.0394 mL | 0.1968 mL | 0.3937 mL | 0.9842 mL | |
| 60 mM | 0.0328 mL | 0.1640 mL | 0.3281 mL | 0.8201 mL | |
| 80 mM | 0.0246 mL | 0.1230 mL | 0.2460 mL | 0.6151 mL | |
| 100 mM | 0.0197 mL | 0.0984 mL | 0.1968 mL | 0.4921 mL |
TCMDC-135051 hydrochloride Related Classifications
HY-126323B Related Classifications
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