1. Anti-infection
  2. Parasite
  3. TCMDC-135051 hydrochloride

TCMDC-135051 hydrochloride 

Cat. No.: HY-126323B
Handling Instructions

TCMDC-135051 hydrochloride is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC50=320 nM).

For research use only. We do not sell to patients.

TCMDC-135051 hydrochloride Chemical Structure

TCMDC-135051 hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 447 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TCMDC-135051 hydrochloride:

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Description

TCMDC-135051 hydrochloride is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC50=320 nM)[1].

In Vitro

TCMDC-135051 hydrochloride shows potent activity against P. berghei sporozoites in a liver invasion and development assay in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM). The kinase assays using recombinant PvCLK3 (P. vivax) and PbCLK3 (P. berghei) show that TCMDC-135051 hydrochloride has near-equipotent inhibition at these two orthologs, with pIC50 values of 7.47 (IC50=0.033 μM) and 7.86 (IC50=0.013 μM), respectively[1].

Molecular Weight

508.05

Formula

C₂₉H₃₄ClN₃O₃

SMILES

O=C(O)C1=CC=C(C2=C3C(NC(C4=C(OC)C=CC(CN(CC)CC)=C4)=C3)=NC=C2)C=C1C(C)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (164.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9683 mL 9.8416 mL 19.6831 mL
5 mM 0.3937 mL 1.9683 mL 3.9366 mL
10 mM 0.1968 mL 0.9842 mL 1.9683 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

TCMDC-135051TCMDC135051TCMDC 135051ParasiteplasmodiumfalciparumproteinkinasemalariaselectiveparasitemutationtranscriptionInhibitorinhibitorinhibit

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Product name:
TCMDC-135051 hydrochloride
Cat. No.:
HY-126323B
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