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Cat. No.: HY-148075

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PI4KIIIbeta-IN-11

PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC₅₀ value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum.

For research use only. We do not sell to patients.

CAS No.: 2365241-79-6
Formula: C₃₃H₃₉N₇O₃
Molecular Weight:581.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

PI4KIIIbeta-IN-11 Chemical Structure

CAS No.: 2365241-79-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC₅₀ value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum^[1]^[2].

IC₅₀ & Target

PI4KIIIβ

9.1 (pIC₅₀)

All PI4K Isoforms :

In Vitro

PI4KIIIβ may be a relevant target protein for inhibition of Hedgehog signaling, and regulates trafficking from the Golgi system to the plasma membrane^[1].
PI4KIIIbeta-IN-11 (compound 22) (0.5 μM; 0-45 min) shows metabolic stability in human microsomes, with the intrinsic clearance of 33.7 mL/min/g^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PI4KIIIbeta-IN-11 (compound 22) (1 mg/kg; i.v.; last over 1 h) displays a low spleen concentration in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar Han Rats^[2]
Dosage:

1 mg/kg
Administration:

Intravenous injection, formulated in 2% DMSO in Kleptose (aq, 10% w/v); over 1 hour; euthanised at 12 h
Result:

Showed a low concentration in spleen of 5.54 ng/g.

Chemical Information

CAS No. 2365241-79-6
Molecular Weight 581.71
Formula C₃₃H₃₉N₇O₃
SMILES

CN1C(C2=CC=CC(CNC3=CC(C(C)(O)C)=NC4=C(C5=CC(C(N(C)[C@@H](C)CO)=O)=C(C=C5)C)C(C)=NN34)=C2)=NC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kremer L, et al. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16617-16628. [Content Brief]

[2]. Barton Nicholas Paul, et al. Preparation of pyrazolopyrimidinamines derivatives as PI4kIII-beta inhibitors: World Intellectual Property Organization, WO2019141694. 2019-07-25.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PI4KIIIbeta-IN-11

All PI4K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PI4KIIIbeta-IN-11 Related Classifications

HY-148075 Related Classifications