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  3. Azlocillin sodium salt

Azlocillin sodium salt (Synonyms: Sodium azlocillin)

Cat. No.: HY-B0529A Purity: ≥98.0%
Handling Instructions

Azlocillin sodium salt (Sodium azlocillin), a semisynthetic penicillin, is a broad spectrum β-lactam antibiotic. Azlocillin sodium salt shows antipseudomonal activity, and also potent against the malarial parasite Plasmodium falciparum.

For research use only. We do not sell to patients.

Azlocillin sodium salt Chemical Structure

Azlocillin sodium salt Chemical Structure

CAS No. : 37091-65-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 96 In-stock
Estimated Time of Arrival: December 31
5 g USD 168 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Description

Azlocillin sodium salt (Sodium azlocillin), a semisynthetic penicillin, is a broad spectrum β-lactam antibiotic. Azlocillin sodium salt shows antipseudomonal activity, and also potent against the malarial parasite Plasmodium falciparum[1][2][3].

IC50 & Target

Bacteria[1]

In Vitro

Over 75% of the isolates of Pseudomonas aeruginosa are inhibited by Azlocillin at a concentration of 12.5 μg/mL. Azlocillin is also active against indole-negative and -positive Proteus spp., inhibiting 98% and 71%, respectively, at a concentration of 12.5 μg/mL. Gram-positive cocci except penicillin G-resistant Staphylococcus aureus are susceptible to Azlocillin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Azlocillin (75 mg/kg) treatment increases the survival of neutropenic mice infected with Escherichia coli or Klebsiella pneumoniae[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

483.47

Formula

C₂₀H₂₂N₅NaO₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.84 mM; Need ultrasonic)

H2O : 6.67 mg/mL (13.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0684 mL 10.3419 mL 20.6838 mL
5 mM 0.4137 mL 2.0684 mL 4.1368 mL
10 mM 0.2068 mL 1.0342 mL 2.0684 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (206.84 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Azlocillin sodium salt
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HY-B0529A
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