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Results for "

rat+brain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (25) Adenosine Receptor (1) Adenylate Cyclase (1) Adrenergic Receptor (23) Akt (3) Angiotensin Receptor (1) Apoptosis (5) ASCT (1) Autophagy (8) Bacterial (8) Biochemical Assay Reagents (1) Bradykinin Receptor (1) Calcium Channel (2) CaMK (1) Cannabinoid Receptor (5) CFTR (1) CGRP Receptor (1) Cholecystokinin Receptor (2) Cholinesterase (ChE) (1) COMT (4) COX (2) CRFR (2) Dopamine Receptor (10) Dopamine Transporter (6) Drug Derivative (4) Drug Isomer (2) Drug Metabolite (1) Endogenous Metabolite (16) Epigenetic Reader Domain (2) ERK (5) FAAH (7) Farnesyl Transferase (1) Fluorescent Dye (1) Fungal (1) GABA Receptor (6) GlyT (2) Heme Oxygenase (HO) (1) Histone Methyltransferase (1) iGluR (5) Interleukin Related (1) Isotope-Labeled Compounds (5) JNK (7) LPL Receptor (1) mAChR (1) Melanocortin Receptor (1) Microtubule/Tubulin (1) Mitophagy (2) Monoamine Oxidase (11) N-myristoyltransferase (1) nAChR (11) Natriuretic Peptide Receptor (NPR) (2) Neurokinin Receptor (3) Neuropeptide Y Receptor (1) Neurotensin Receptor (4) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (3) Orexin Receptor (OX Receptor) (4) P2X Receptor (1) Parasite (1) PDI (3) Phosphodiesterase (PDE) (2) PKC (12) Potassium Channel (6) Prolyl Endopeptidase (PREP) (1) Reference Standards (20) SARS-CoV (1) Serotonin Transporter (1) Sodium Channel (2) Somatostatin Receptor (1) Succinate Dehydrogenase (1) Trk Receptor (3) TRP Channel (2) γ-secretase (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (16) Endocrinology (11) Infection (14) Inflammation/Immunology (11) Metabolic Disease (26) Neurological Disease (129)
Click Chemistry:	Alkynes (5)
Oligonucleotides:	Guanosine (1) Nucleoside Analogs (1)

178

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15084

Dizocilpine maleate Maximum Cited Publications 44 Publications Verification (+)-MK 801 Maleate	iGluR	Neurological Disease
Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with K_d of 37.2 nM in rat brain membranes.

HY-15084B

Dizocilpine Maximum Cited Publications 44 Publications Verification MK-801	iGluR	Neurological Disease
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a K_d of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca ²⁺ flux .

HY-B1614

Clenbuterol hydrochloride 5+ Cited Publications NAB-365 hydrochloride	Adrenergic Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage .

HY-109012

Seltorexant 3 Publications Verification JNJ-42847922	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pK_i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .

HY-14605A

Rasagiline Maximum Cited Publications 7 Publications Verification (R)-AGN1135; TVP1012	Monoamine Oxidase	Neurological Disease
Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10864

URB-597 5 Publications Verification KDS-4103	FAAH Autophagy Mitophagy	Neurological Disease
URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC₅₀s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity .

HY-13290

KN-62 10+ Cited Publications	CaMK P2X Receptor	Metabolic Disease Cancer
KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a K_i of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X₇ receptors in HEK293 cells, with an IC₅₀ value of approximately 15 nM.

HY-14605

Rasagiline mesylate Maximum Cited Publications 7 Publications Verification (R)-AGN1135 mesylate; TVP1012 mesylate	Monoamine Oxidase Autophagy Apoptosis	Neurological Disease
Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-109012A

Seltorexant hydrochloride 3 Publications Verification JNJ-42847922 hydrochloride	Orexin Receptor (OX Receptor)	Neurological Disease Metabolic Disease
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pK_i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .

HY-18698

L-701324	iGluR	Neurological Disease
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC₅₀=2 nM). L-701324 has antidepressant activity .

HY-19740

BIA 10-2474 2 Publications Verification	FAAH Autophagy	Neurological Disease
BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC₅₀ values of 50 to 70mg/kg in various rat brain regions.

HY-N2080

Songorine	GABA Receptor	Neurological Disease Cancer
Songorine is a BBB-permeable diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC) .

HY-10862

FAAH inhibitor 1 Benzothiazole analog 3	FAAH Autophagy	Neurological Disease Cancer
FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor. FAAH inhibitor 1 has no off-target activity with respect to other serine hydrolases. FAAH inhibitor 1 is exclusively specific against FAAH in rat brain with an IC₅₀ value of 18 nM and had no missing protein bands in all the other tissues. FAAH inhibitor 1 can be used for neurological disorders research .

HY-14174

MRK-560 4 Publications Verification	γ-secretase	Neurological Disease Cancer
MRK-560, a chemical probe, is an orally active, brain barrier-penetrated γ-Secretase inhibitor, reducing Aβ peptide in rat brain and cerebrospinal fluid. MRK-560 decreases mutant NOTCH1 processing by selectively inhibiting PSEN1. MRK-560 can be used in studies of Alzheimer's disease and T-cell acute lymphoblastic leukaemia (T-ALL) .

HY-N13258

β-Citryl-L-glutamic acid β-Citrylglutamic acid	Others	Others
β-Citryl-L-glutamic acid (β-Citrylglutamic acid) is a citrylglutamic acid, that can be isolated from newborn rat brain .

HY-13929

Isocarboxazid 2 Publications Verification	Monoamine Oxidase	Neurological Disease
Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC₅₀ of 4.8 μM for rat brain monoamine oxidase in vitro .

HY-W020468

Linopirdine 2 Publications Verification DuP 996	Potassium Channel TRP Channel	Neurological Disease
Linopirdine (DuP 996) is an orally active, selective M-type K ⁺ current (IM; Kv7; KCNQ Channels) inhibitor with an IC₅₀ of 2.4 μM. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing agent, increases acetylcholine release in rat brain tissue .

HY-108483

RP 67580	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a K_i value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation .

HY-100792

URB602	Bacterial	Cancer
URB602 is a selective monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL with IC₅₀ of 28±4 μM through a noncompetitive mechanism.

HY-112552

1,2-Distearoyl-sn-glycerol DSG; 1,2-Dioctadecanoyl-sn-glycerol	Endogenous Metabolite Biochemical Assay Reagents	Others
1,2-Distearoyl-sn-glycerol (DSG) is a glyceride compound. 1,2-Distearoyl-sn-glycerol can be used as an internal standard for the analysis of molecular species of diacylglycerol (DAG) and other phospholipids in rat brain .

HY-P1091

Hemopressin (human, mouse)	Cannabinoid Receptor	Neurological Disease
Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models .

HY-120170

BMS-466442 1 Publications Verification	ASCT Adrenergic Receptor Dopamine Transporter	Neurological Disease
BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC₅₀ of 11 nM. BMS-466442 inhibits [ ³H] D-serine uptake into rat brain synaptosomes, with an IC₅₀ of 400 nM. BMS-466442 can be used for schizophrenia research .

HY-131693A

γ-Acetylenic GABA hydrochloride GAG hydrochloride	GABA Receptor	Neurological Disease Cancer
γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride can increase the concentration of GABA in rat brain . γ-Acetylenic GABA (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-NP180

Progesterone/BSA	Calcium Channel	Metabolic Disease
Progesterone/BSA is a conjugate of Progesterone (HY-N0437) and bovine serum albumin (BSA). Progesterone/BSA cannot penetrate the plasma membrane of human sperm, but still rapidly elevates intracellular free calcium and induces the acrosome reaction. Progesterone/BSA can also act as a probe to specifically bind to progesterone-binding proteins on the membrane of rat brain synaptosomes .

HY-14200

(S)-Rasagiline 1 Publications Verification TVP1022; S-PAI	Monoamine Oxidase	Neurological Disease
(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible MAO inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-150209

MODAG-001	Fluorescent Dye	Neurological Disease
MODAG-001 can bind to synuclein fibrils in a rat brain. MODAG-001 is a candidate α-syn imaging probe .

HY-W009234

6-Chloroguanineriboside 6-Chloroguanosine	Nucleoside Antimetabolite/Analog	Others
6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analog. 6-Chloroguanineriboside has extremely low affinity for guanosine binding sites in rat brain (K_i: 253.1 μM) .

HY-120963

N-Oleoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine and N-arachidonoyl serine, have been isolated and characterized from bovine brain.1 During mass spectral lipidomics analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, were discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Oleoyl taurine is an amino-acyl endocannabinoid isolated from rat brain that may activate TRPV1 and TRPV4.

HY-108295

Pivagabine CXB-722	GABA Receptor	Neurological Disease
Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain .

HY-P1090

Hemopressin(rat)	Cannabinoid Receptor	Neurological Disease
Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models .

HY-W795507

Cyanopindolol	Adrenergic Receptor 5-HT Receptor	Neurological Disease
Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (K_i: 2.1 and 3 nM respectively) .

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Neurological Disease Metabolic Disease
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

HY-120965

N-Palmitoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered. N-Palmitoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling. Its function is currently under investigation.

HY-101169

Tetrindole mesylate 1 Publications Verification	Monoamine Oxidase	Neurological Disease
Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a K_i value of 0.4 μM and inhibits MAO B with a K_i of 110 μM. Tetrindole mesylate has antidepressant activity .

HY-P1303

CART(62-76)(human,rat)	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain .

HY-P1573

Brain Natriuretic Peptide-45, rat BNP-45, rat	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Brain Natriuretic Peptide-45, rat (BNP-45, rat) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency .

HY-P1519

Brain Natriuretic Peptide (1-32), rat BNP (1-32), rat	Angiotensin Receptor	Cardiovascular Disease
Brain Natriuretic Peptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) .

HY-120964

N-Stearoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Stearoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling.

HY-116663

(±)20-HDHA (±)20-HDoHE	Endogenous Metabolite	Neurological Disease
(±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate .

HY-101169A

Tetrindole hydrochloride	Monoamine Oxidase	Neurological Disease
Tetrindole hydrochloride is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole hydrochloride inhibits rat brain mitochondrial MAO A in a competitive manner with a K_i value of 0.4 μM and inhibits MAO B with a K_i of 110 μM. Tetrindole hydrochloride has antidepressant activity .

HY-165116

1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE 18:0p/22:6-PE; C18(Plasm)-22:6-PE; PE(P-18:0/22:6)	Endogenous Metabolite	Others
1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p/22:6-PE) is a lipid identified in rat brain tissue by mass spectrometry imaging with specific structural and distribution characteristics, and isomers of different fatty acid chains can be identified by improved methods.

HY-126419

Kobophenol A	SARS-CoV PKC	Infection
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC₅₀ of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC₅₀ of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC₅₀ of 52 µM .

HY-108973A

Ifoxetine CGP-15210G	5-HT Receptor	Neurological Disease
Ifoxetine (CGP 15210G) is an inhibitor of 5-HT reuptake. Ifoxetine specifically and selectively blocks the 5-HT reuptake in the brain without affecting the 5-HT uptake processes in the periphery (blood platelets). Ifoxetine inhibits the uptake of radiolabelled 5-HT into rat brain synaptosomes in vitro or ex vivo. Ifoxetine has antidepressant properties .

HY-P3883

[DAla4] Substance P (4-11)	Neurokinin Receptor	Neurological Disease
[DAla4] Substance P (4-11) is an analog of Substance P (HY-P0201) that inhibits the binding of ¹²⁵I-Bolton Hunter-conjugated Eledoisin (HY-P0006) (IC₅₀ of 0.5 μM) and ¹²⁵I-Bolton Hunter-conjugated Substance P (IC₅₀ of 0.15 μM) to rat brain cortex membranes .

HY-19578B

Isamoltane hemifumarate (±)-Isamoltane hemifumarate	5-HT Receptor Adrenergic Receptor	Neurological Disease
Isamoltane hemifumarate is a selective antagonist of 5-HT_1B receptor, with an IC₅₀ of 39 nM for inhibits the binding of [ ¹²⁵I]ICYP to 5-HT_1B recognition sites in rat brain membranes. Isamoltane hemifumarate is also a β-adrenoceptor ligand, with an IC₅₀ of 8.4 nM. Isamoltane hemifumarate shows anxiolytic activity .

HY-13225A

Rivanicline RJR-2403; (E)-Metanicotine	nAChR	Neurological Disease
Rivanicline (RJR-2403) is a neuronal nicotinic receptor agonist. Rivanicline is highly selective for the rat brain cortex nAChRs (K_i = 26 nM, EC₅₀ of 732 nM) and α4β2 subtype (K_i = 26 nM, EC₅₀ = 16 μM). Rivanicline can significantly restore the learning impairment and cognitive dysfunction. Rivanicline can be used for the study of neurodegenerative diseases (such as schizophrenia or Alzheimer's disease) .

HY-W098008

Fenbendazole analog-1	Parasite Microtubule/Tubulin	Infection
Fenbendazole analog-1 (compound 9) is a 2-methoxycarbonylamino-derived antiparasitic compound and inhibits rat brain tubulin polymerization. Fenbendazole analog-1 inhibits the growth of the protozoa Giardia lamblia, Entamoeba histolytica, and the worm Trichinella spiralis .

HY-120965S

N-Palmitoyl Taurine-d4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
N-Palmitoyl taurine-d₄ is the deuterium labeled N-Palmitoyl taurine (HY-120965). N-Palmitoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling. Its function is currently under investigation .

HY-135507

NAS-181	5-HT Receptor	Neurological Disease
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an K_i value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions .

HY-U00322

5-HT3 antagonist 3	5-HT Receptor	Neurological Disease
5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with K_i of 0.25 nM .

Cat. No.	Product Name	Target	Research Area

HY-P1091

Hemopressin (human, mouse)	Cannabinoid Receptor	Neurological Disease
Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models .

HY-P1090

Hemopressin(rat)	Cannabinoid Receptor	Neurological Disease
Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models .

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Neurological Disease Metabolic Disease
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

HY-P10153

gH625	Peptides	Others
gH625 is a cell-penetrating viral peptide which is a part of glycoprotein H of Herpes simplex virus type I. gH625 is able to cross the cell membrane and to transport many conjugated cargoes into the cytosol. gH625 is permeable to the blood-brain barrier (BBB) and can enter the rat brain in vivo without toxic effects. gH625 can be used for siRNA delivery research .

HY-P1106A

K41498 TFA	CFTR	Cardiovascular Disease
K41498 TFA is a highly selective CRF 2 receptor antagonist, with a K_i of 0.66 nM for human CRF2α receptor and a K_i of 0.62 nM for human CRF2β receptor. K41498 TFA inhibits cAMP accumulation in cells expressing CRF2. K41498 TFA antagonizes the hypotensive response induced by systemic administration of urocortin in conscious rats. K41498 TFA undergoes radioiodination without loss of activity and serves for autoradiographic studies of native CRF2 receptors in rat brain and peripheral tissues .

HY-P1303

CART(62-76)(human,rat)	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain .

HY-P1106

K41498	CRFR	Cardiovascular Disease
K41498 is a highly selective CRF 2 receptor antagonist, with a K_i of 0.66 nM for human CRF2α receptor and a K_i of 0.62 nM for human CRF2β receptor. K41498 inhibits cAMP accumulation in cells expressing CRF2. K41498 antagonizes the hypotensive response induced by systemic administration of urocortin in conscious rats. K41498 undergoes radioiodination without loss of activity and serves for autoradiographic studies of native CRF2 receptors in rat brain and peripheral tissues .

HY-P3071

ShK toxin Stichodactyla helianthus neurotoxin	Potassium Channel	Neurological Disease Inflammation/Immunology
ShK toxin blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .

HY-P1573

Brain Natriuretic Peptide-45, rat BNP-45, rat	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Brain Natriuretic Peptide-45, rat (BNP-45, rat) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency .

HY-P1519

Brain Natriuretic Peptide (1-32), rat BNP (1-32), rat	Angiotensin Receptor	Cardiovascular Disease
Brain Natriuretic Peptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) .

HY-P3883

[DAla4] Substance P (4-11)	Neurokinin Receptor	Neurological Disease
[DAla4] Substance P (4-11) is an analog of Substance P (HY-P0201) that inhibits the binding of ¹²⁵I-Bolton Hunter-conjugated Eledoisin (HY-P0006) (IC₅₀ of 0.5 μM) and ¹²⁵I-Bolton Hunter-conjugated Substance P (IC₅₀ of 0.15 μM) to rat brain cortex membranes .

HY-P3071A

ShK toxin TFA Stichodactyla helianthus neurotoxin TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
ShK toxin TFA (Stichodactyla helianthus neurotoxin TFA) is a neurotoxin. ShK toxin TFA blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin TFA can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin TFA competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin TFA suppresses K ⁺ currents in cultured rat dorsal root ganglion neurons. ShK toxin TFA also inhibits T lymphocyte proliferation .

HY-P3964

TRH Precursor Peptide	Endogenous Metabolite	Endocrinology
TRH Precursor Peptide is a precursor peptide of thyrotropin-releasing hormone (TRH). TRH Precursor Peptide formation of TRH in rat brain and pituitary is zinc-dependent .

HY-P1573A

Brain Natriuretic Peptide-45, rat TFA BNP-45, rat TFA	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency .

HY-19648B

Ebiratide TFA HOE-427 TFA	nAChR	Neurological Disease
Ebiratide (HOE-427) TFA is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide TFA enhances acetycholine (ACh) metabolism in rat brain .

HY-19648

Ebiratide HOE-427 free base	Melanocortin Receptor nAChR	Neurological Disease
Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain .

HY-P2457

rCRAMP (rat)	Bacterial	Infection Inflammation/Immunology
rCRAMP (rat) is the rat cathelin-related antimicrobial peptide. rCRAMP (rat) contributes to the antibacterial activity in rat brain peptide/protein extracts. rCRAMP (rat) is a potential key player in the innate immune system of rat CNS .

HY-P1239

Neuromedin S(rat)	Peptides	Neurological Disease
Neuromedin S(rat) is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain. Neuromedin S acts as a ligand for the G protein-coupled receptor FM4/TGR-1

HY-P1239A

Neuromedin S(rat) TFA	Peptides	Neurological Disease
Neuromedin S(rat) TFA is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain. Neuromedin S acts as a ligand for the G protein-coupled receptor FM4/TGR-1

HY-P1091A

Hemopressin(human, mouse) TFA	Cannabinoid Receptor	Neurological Disease
Hemopressin TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin TFA exerts antinociceptive action in inflammatory pain models .

HY-P1303A

CART(62-76)(human,rat) TFA	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) TFA is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) TFA can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain .

HY-P1090A

Hemopressin(rat) TFA	Cannabinoid Receptor	Neurological Disease
Hemopressin(rat) TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) TFA exerts antinociceptive action in inflammatory pain models .

HY-P1134

Galanin (1-15) (porcine, rat)	5-HT Receptor	Neurological Disease
Galanin (1-15) (porcine, rat) is the N-terminal 15 amino acids peptide fragment of the neuropeptide galanin. Galanin (1-15) (porcine, rat) interacts with the 5-HT1A receptor in the dorsal hippocampus of the rat brain, reduces the affinity of 5-HT1A receptors, and regulates the serotonin neuronal networks .

HY-P1318

Ac-RYYRIK-NH2	Opioid Receptor	Neurological Disease
Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (K_d=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [ ³⁵S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain .

HY-P1318A

Ac-RYYRIK-NH2 TFA	Opioid Receptor	Neurological Disease
Ac-RYYRIK-NH2 TFA is a potent and partial agonist on ORL1 transfected in CHO cells (K_d=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [ ³⁵S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain .

HY-P2601A

Tyr-α-CGRP (human) TFA	CGRP Receptor	Others
Tyr-α-CGRP (human) TFA is an N-terminally extended human α-CGRP analog. Tyr-α-CGRP (human) TFA can bind to membrane preparations from rat brain and spleen with IC₅₀ values of 0.2 nM and 0.5 nM, respectively, and induce positive chronotropic and inotropic effects in isolated guinea pig right and left atria with EC₅₀ values of 282 nM and 74 nM, respectively. Tyr-α-CGRP (human) TFA also inhibits contractile responses in rat vas deferens with an EC₅₀ value of 1.9 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0573

Propranolol hydrochloride Maximum Cited Publications 44 Publications Verification	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Bacterial
Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573B

Propranolol Maximum Cited Publications 44 Publications Verification	Cardiovascular Disease Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Adrenergic Receptor Bacterial
Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B1614

Clenbuterol hydrochloride 5+ Cited Publications NAB-365 hydrochloride	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor
Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage .

HY-W012530

Phenylpyruvic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite PDI
Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .

HY-N2080

Songorine	Alkaloids Structural Classification Aconitum soongaricum Stapf Classification of Application Fields Other Alkaloids Ranunculaceae Plants Disease Research Fields Source Classification Cancer	GABA Receptor
Songorine is a BBB-permeable diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC) .

HY-N13258

β-Citryl-L-glutamic acid β-Citrylglutamic acid	Animals Ketones, Aldehydes, Acids Source Classification	Others
β-Citryl-L-glutamic acid (β-Citrylglutamic acid) is a citrylglutamic acid, that can be isolated from newborn rat brain .

HY-112552

1,2-Distearoyl-sn-glycerol DSG; 1,2-Dioctadecanoyl-sn-glycerol	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Lipid Source Classification	Endogenous Metabolite Biochemical Assay Reagents
1,2-Distearoyl-sn-glycerol (DSG) is a glyceride compound. 1,2-Distearoyl-sn-glycerol can be used as an internal standard for the analysis of molecular species of diacylglycerol (DAG) and other phospholipids in rat brain .

HY-W012530R

Phenylpyruvic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Endogenous Metabolite PDI
Phenylpyruvic acid (Standard) is the analytical standard of Phenylpyruvic acid. This product is intended for research and analytical applications. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .

HY-B0573R

Propranolol hydrochloride (Standard)	Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Bacterial
Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-116663

(±)20-HDHA (±)20-HDoHE	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
(±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate .

HY-126419

Kobophenol A	Infection Classification of Application Fields Cyperaceae Phenols Polyphenols Plants Disease Research Fields Source Classification Carex kobomugi Ohwi	SARS-CoV PKC
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC₅₀ of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC₅₀ of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC₅₀ of 52 µM .

HY-114651

Phenazoviridin	Microorganisms Saccharides Monosaccharides Source Classification	Others
Phenazoviridin is a free radical scavenger. Phenazoviridin shows strong inhibitory activity against lipid peroxidation in rat brain homogenate and exhibits antihypoxic activity in mice .

HY-100821

2,4-Dihydroxyphenylacetylasparagine	Animals Ketones, Aldehydes, Acids Phenols Source Classification	Bacterial
2,4-Dihydroxyphenylacetylasparagine is a potent and selective antagonist of glutamate. 2,4-Dihydroxyphenylacetylasparagine inhibits glutamate binding to rat brain synaptic membranes .

HY-113516

20-HETE Ethanolamide	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
20-HETE Ethanolamide is a metabolite of endocannabinoid Anandamide. 20-HETE Ethanolamide binds to the rat brain cannabinoid CB1 receptor with a K_i of 985 nM .

HY-N14663

Griseolic acid C Dihydrodeoxygriseolic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
Griseolic acid C (Dihydrodeoxygriseolic acid) is an antibiotic. Griseolic acid C can be found in Streptomyces griseoaurantiacus SANK43894. Griseolic acid C has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with an IC₅₀ of 0.12 μM (extracted from rat brain) .

HY-N15282

Broussoflavonol G	Flavonols Flavonoids Plants Moraceae Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat Source Classification	Interleukin Related
Broussoflavonol G is an active ingredient of Moraceae plants, which can be isolated from Broussonetia papyrifera. Broussoflavonol G can effectively inhibit Fe ²⁺-induced lipid oxidation in rat brain homogenate and significantly inhibit the proliferation of rat vascular smooth muscle cells .

HY-B1614R

Clenbuterol hydrochloride (Standard) NAB-365 hydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor
Clenbuterol (hydrochloride) (Standard) is the analytical standard of Clenbuterol (hydrochloride). This product is intended for research and analytical applications. Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage .

Cat. No.	Product Name	Chemical Structure

HY-B0573S1

Propranolol-d7 (ring-d7)

Propranolol-d₇ (ring-d₇) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573BS

Propranolol-d7

Propranolol-d₇ is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573S

Propranolol-d7 hydrochloride

Propranolol-d₇ (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-14280S

Entacapone-d10

Entacapone-d₁₀ is the deuterium labeled Entacapone. Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC₅₀ values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC₅₀s>50 μM). Entacapone can be used for the research of Parkinson's disease . Entacapone serves as a inhibitor of FTO demethylation with an IC₅₀ of 3.5 μM, can be used for the research of metabolic disorders .

HY-120965S

N-Palmitoyl Taurine-d4
N-Palmitoyl taurine-d₄ is the deuterium labeled N-Palmitoyl taurine (HY-120965). N-Palmitoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling. Its function is currently under investigation .

HY-120964S

N-Stearoyl Taurine-d4
N-Stearoyl Taurine-d₄ is the deuterium labeled N-Stearoyl taurine (HY-120964). N-Stearoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling .

HY-14605S

Rasagiline-13C3 mesylate
Rasagiline- ¹³C₃ ((R)-AGN1135- ¹³C₃; TVP1012- ¹³C₃) mesylate is the deuterium labeled Rasagiline (mesylate) (HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively .

HY-B1110S

Nomifensine-d3 maleate

Nomifensine-d₃ ((±)-Nomifensine-d₃) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-18610S

Diclofensine-d3 hydrochloride

Diclofensine-d₃ (Ro-8-4650-d₃) hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC₅₀ values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.

Cat. No.	Product Name		Classification