Nomifensine (Standard)
Nomifensine (Standard) is the analytical standard of Nomifensine. This product is intended for research and analytical applications. Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine has antidepressant and analgesic effects. Nomifensine is used in neurodegenerative diseases, compound addiction, and pain research.
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- Pureté : 98%
- CAS No.: 24526-64-5
- Formule: C16H18N2
- Masse moléculaire:238.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-B1110
NomifensineNorepinephrine/Dopamine Reuptake Inhibitor -
HY-14538
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SCH-23390 hydrochlorideDopamine D1 Receptor Antagonist -
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Nomifensine maleateNorepinephrine/Dopamine Reuptake Inhibitor -
HY-17382
Metoclopramide5-HT3/D2 Receptor Antagonist -
HY-B0410
PramipexoleDopamine Receptor Agonist -
HY-B1240
DroperidolDopamine Receptor Antagonist -
HY-N0925
TetrahydroberberineDopamine Receptor Antagonist -
HY-B0735A
Fenoldopam mesylateDopamine DA Receptor Agonist -
HY-A0081
Fluphenazine dihydrochlorideDopamine Receptor Inhibitor -
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ChlorprothixeneNeuroprotective Agent -
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PD-168077 maleateDopamine Receptor Agonist
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 24526-64-5
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Masse moléculaire 238.33
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Formule C16H18N2
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SMILES
NC1=CC=CC2=C1CN(C)CC2C3=CC=CC=C3
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Synonyms
(±)-Nomifensine (Standard); Nomifensin (Standard)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44(5):1615-22. [Content Brief]
[2]. Tuomisto J. Nomifensine and its derivatives as possible tools for studying amine uptake. Eur J Pharmacol. 1977 Mar 21;42(2):101-6. [Content Brief]
[3]. Tejani-Butt S, et al. Strain-dependent modification of behavior following antidepressant treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):7-14. [Content Brief]
[4]. Katz NS, et al. Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J Psychopharmacol. 2010 Aug;24(8):1223-35. [Content Brief]
[5]. Kang SH, et al. Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells. Exp Ther Med. 2022 Apr;23(4):306. [Content Brief]
[6]. Gilbert AK, et al. Characterization of the analgesic properties of nomifensine in rats. Pharmacol Biochem Behav. 2001 Apr;68(4):783-7. [Content Brief]
[7]. Melamed E, et al. Suppression of MPTP-induced dopaminergic neurotoxicity in mice by nomifensine and L-DOPA. Brain Res. 1985 Sep 9;342(2):401-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nomifensine (Standard) Related Classifications
HY-B1110R Related Classifications
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