2. Tetrindole mesylate

Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity.

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Tetrindole mesylate Chemical Structure

Tetrindole mesylate Chemical Structure

CAS No. : 170964-68-8

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Tetrindole mesylate Related Antibodies

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Description

Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity[1][2].

In Vitro

Tetrindole mesylate has IC50s of 0.51-1.37 μM for 6 human breast tumor cell lines (MCF-7, HCC1954, T47D, MDA-MB-157, ZR75-1, BT474)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrindole mesylate Related Antibodies
In Vivo

Tetrindole mesylate (25 mg/kg; po; single dose) inhibits rat brain and liver mitochondrial MAO A by 80% within 0.5-1 hr and the onset of recovery of enzyme activity became evident after 24 hr in male albino rats weighing 180-200 g[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

390.54

Formula

C21H30N2O3S
CAS No.
SMILES

CS(=O)(O)=O.N12C3=C(C4=C1C(NCC2)CCC4)C=C(C5CCCCC5)C=C3
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrindole170964-68-8Inhibitorinhibitorinhibit

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