Tetrindole free base
Based on 1 publication(s) in Google Scholar
Tetrindole free base is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole free base inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole free base has antidepressant activity.
For research use only. We do not sell to patients.
- CAS No.: 170964-67-7
- Formula: C20H26N2
- Molecular Weight:294.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Tetrindole free base
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Biological Activity
Description
IC50 & Target
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MAO-A |
In Vitro
Tetrindole free base has IC50s of 0.51-1.37 μM for 6 human breast tumor cell lines (MCF-7, HCC1954, T47D, MDA-MB-157, ZR75-1, BT474)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 170964-67-7
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Appearance Solid
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Molecular Weight 294.44
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Formula C20H26N2
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SMILES
C1=CC2=C(C=C1C3CCCCC3)C4=C5N2CCNC5CCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. A E Medvedev, et al. Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol. 1994 Jan 20;47(2):303-8. [Content Brief]
[2]. William D Gwynne, et al. Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells. Cell Mol Biol Lett. 2019 Nov 12;24:59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tetrindole free base Related Classifications
HY-W676790 Related Classifications
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