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Cat. No.: HY-W676790

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Tetrindole free base

Name: Tetrindole free base
Brand: MedChemExpress
SKU: HY-W676790
Availability: PreOrder

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

Tetrindole free base is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole free base inhibits rat brain mitochondrial MAO A in a competitive manner with a K_i value of 0.4 μM and inhibits MAO B with a K_i of 110 μM. Tetrindole free base has antidepressant activity.

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CAS No.: 170964-67-7
화학식: C₂₀H₂₆N₂
분자량:294.44

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Tetrindole free base Chemical Structure

CAS No.: 170964-67-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target

MAO-A

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

Tetrindole free base has IC₅₀s of 0.51-1.37 μM for 6 human breast tumor cell lines (MCF-7, HCC1954, T47D, MDA-MB-157, ZR75-1, BT474)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tetrindole (25 mg/kg; po; single dose) free base inhibits rat brain and liver mitochondrial MAO A by 80% within 0.5-1 hr and the onset of recovery of enzyme activity became evident after 24 hr in male albino rats weighing 180-200 g^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 170964-67-7
Appearance Solid
분자량 294.44
화학식 C₂₀H₂₆N₂
Color White to off-white
SMILES

C1=CC2=C(C=C1C3CCCCC3)C4=C5N2CCNC5CCC4
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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iScience

2026 Feb 11;29(3).

순도&문서

Handling Instructions (2659 KB)

References

[1]. A E Medvedev, et al. Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol. 1994 Jan 20;47(2):303-8. [Content Brief]

[2]. William D Gwynne, et al. Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells. Cell Mol Biol Lett. 2019 Nov 12;24:59. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Tetrindole free base

1 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References

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Tetrindole free base

Publications Citing Use of MedChemExpress (MCE) Tetrindole free base

All Monoamine Oxidase Isoforms