Tetrindole free base
Based on 1 publication(s) in Google Scholar
Tetrindole free base is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole free base inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole free base has antidepressant activity.
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- CAS No.: 170964-67-7
- Formula: C20H26N2
- Molecular Weight:294.44
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tetrindole free base
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Biological Activity
Description
IC50 & Target
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MAO-A |
In Vitro
Tetrindole free base has IC50s of 0.51-1.37 μM for 6 human breast tumor cell lines (MCF-7, HCC1954, T47D, MDA-MB-157, ZR75-1, BT474)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 170964-67-7
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Appearance Solid
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Molecular Weight 294.44
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Formula C20H26N2
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Color White to off-white
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SMILES
C1=CC2=C(C=C1C3CCCCC3)C4=C5N2CCNC5CCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Protocols
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Protocol for Tail Suspension Test (TST)
The Tail Suspension Test is a mouse behavioral assay in which an animal is suspended by the tail in an inescapable position, causing alternating escape-directed activity and immobility; the main readout is immobility time, and antidepressant-like treatments generally reduce immobility compared with vehicle controls. The assay detects behavioral response to acute inescapable stress rather than a molecular event; immobility is interpreted as passive stress-coping behavior, while reduced immobility is used as a predictive screen for antidepressant-like activity, with important limitations related to strain, locomotor activity, and tail-climbing behavior.
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Protocol for Forced Swim Test (FST)
The Forced Swim Test is a rodent behavioral assay in which a mouse or rat is placed in an inescapable cylinder of water, and the main readout is the time spent immobile versus active escape-related behaviors such as swimming or climbing. Reduced immobility after treatment has historically been interpreted as antidepressant-like activity, but the assay should be interpreted as a behavioral response to acute inescapable stress rather than a complete model of human depression.
Purity & Documentation
References
[1]. A E Medvedev, et al. Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol. 1994 Jan 20;47(2):303-8. [Content Brief]
[2]. William D Gwynne, et al. Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells. Cell Mol Biol Lett. 2019 Nov 12;24:59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tetrindole free base Related Classifications
HY-W676790 Related Classifications
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