170964-67-7
170964-67-7
Chemical Structure
Tetrindole free base
- CAS No.: 170964-67-7
- Formula:C20H26N2
- Molecular Weight:294.44
IUPAC Name: 8-cyclohexyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole
InChIKey: AUXCHYJDVJZEPG-UHFFFAOYSA-N
SMILES: C1=CC2=C(C=C1C3CCCCC3)C4=C5N2CCNC5CCC4
Biological Activity: Tetrindole free base is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole free base inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole free base has antidepressant activity[1][2].
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Tetrindole free base | Tetrindole free base is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole free base inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole free base has antidepressant activity. | |||||||||||||||||||||
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References
- [1]. A E Medvedev, et al. Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol. 1994 Jan 20;47(2):303-8. [Content Brief]
- [2]. William D Gwynne, et al. Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells. Cell Mol Biol Lett. 2019 Nov 12;24:59. [Content Brief]
