WIN 64338 hydrochloride
WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 163727-74-0
- Formel: C45H69Cl2N4OP
- Molecular Weight:783.94
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
Bradykinin B2 Receptor (B2R) |
WIN 64338 hydrochloride competitively inhibits Bradykinin-stimulated 45Ca2+ efflux from IMR-90 cells (pA2=7.1)[1].
WIN 64338 hydrochloride inhibits Bradykinin-mediated guinea pig ileum contractility (pA2=8.2)[1].
WIN 64338 hydrochloride inhibits Bradykinin-induced contraction of guinea-pig trachea, with a KB of 64.3 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 163727-74-0
-
Molecular Weight 783.94
-
Formel C45H69Cl2N4OP
-
SMILES
O=C(NC1=CC=C(C[P+](CCCC)(CCCC)CCCC)C=C1)[C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC=C5C=CC=CC5=C4.[Cl-].Cl
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Sawutz DG, et, al. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4693-7. [Content Brief]
[2]. Scherrer D, et, al. Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br J Pharmacol. 1995 Aug;115(7):1127-8. [Content Brief]
[3]. Rouhiaine A, et, al. The bradykinin system in stress and anxiety in humans and mice. Sci Rep. 2019 Dec 19;9(1):19437. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
WIN 64338 hydrochloride Related Classifications
HY-101368A Related Classifications
Powered by Bioz