WIN 64338 hydrochloride
Based on 1 Customer Validation
WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM).
For research use only. We do not sell to patients.
- Purity: 98.77%
- CAS No.: 163727-74-0
- Formula: C45H69Cl2N4OP
- Molecular Weight:783.94
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-17446
Icatibant
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HY-103290
R715
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HY-15043
ELN-441958
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![Sar-[D-Phe8]-des-Arg9-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103291.gif)
HY-103291
Sar-[D-Phe8]-des-Arg9-Bradykinin
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HY-103289
MEN 11270
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HY-17446R
Icatibant (Standard)
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HY-103293
Lys-Bradykinin
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![Lys-[Des-Arg9]Bradykinin](https://file.medchemexpress.com/product_pic/hy-103295.gif)
HY-103295
Lys-[Des-Arg9]Bradykinin
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HY-103296
Bombinakinin M
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HY-103294
R892
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![[Phe8Ψ(CH-NH)Arg9]-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103292.gif)
HY-103292
[Phe8Ψ(CH-NH)Arg9]-Bradykinin
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HY-108896
Icatibant acetate
All Bradykinin Receptor Isoforms
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Biological Activity
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Bradykinin B2 Receptor (B2R) |
WIN 64338 hydrochloride competitively inhibits Bradykinin-stimulated 45Ca2+ efflux from IMR-90 cells (pA2=7.1)[1].
WIN 64338 hydrochloride inhibits Bradykinin-mediated guinea pig ileum contractility (pA2=8.2)[1].
WIN 64338 hydrochloride inhibits Bradykinin-induced contraction of guinea-pig trachea, with a KB of 64.3 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 163727-74-0
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Appearance Solid
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Molecular Weight 783.94
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Formula C45H69Cl2N4OP
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Color White to off-white
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SMILES
O=C(NC1=CC=C(C[P+](CCCC)(CCCC)CCCC)C=C1)[C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC=C5C=CC=CC5=C4.[Cl-].Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sawutz DG, et, al. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4693-7. [Content Brief]
[2]. Scherrer D, et, al. Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br J Pharmacol. 1995 Aug;115(7):1127-8. [Content Brief]
[3]. Rouhiaine A, et, al. The bradykinin system in stress and anxiety in humans and mice. Sci Rep. 2019 Dec 19;9(1):19437. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WIN 64338 hydrochloride Related Classifications
HY-101368A Related Classifications
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