1. GPCR/G Protein
    Neuronal Signaling
  2. Bradykinin Receptor
    mAChR
  3. WIN 64338 hydrochloride

WIN 64338 hydrochloride 

Cat. No.: HY-101368A
Handling Instructions

WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM).

For research use only. We do not sell to patients.

WIN 64338 hydrochloride Chemical Structure

WIN 64338 hydrochloride Chemical Structure

CAS No. : 163727-74-0

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM)[1][2].

IC50 & Target

Ki: 64 nM (bradykinin B2 receptor)[1], 350 nM (muscarinic receptor)[2]

In Vitro

WIN 64338 hydrochloride competitively inhibits Bradykinin-stimulated 45Ca2+ efflux from IMR-90 cells (pA2=7.1)[1].
WIN 64338 hydrochloride inhibits Bradykinin-mediated guinea pig ileum contractility (pA2=8.2)[1].
WIN 64338 hydrochloride inhibits Bradykinin-induced contraction of guinea-pig trachea, with a KB of 64.3 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WIN 64338 (5 mg/kg; i.p.) hydrochloride decreases the physiological anxiety measure, stress-induced hyperthermia (SIH) of mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

783.94

Formula

C45H69Cl2N4OP

CAS No.
SMILES

O=C(NC1=CC=C(C[P+](CCCC)(CCCC)CCCC)C=C1)[[email protected]@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC=C5C=CC=CC5=C4.[Cl-].Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
WIN 64338 hydrochloride
Cat. No.:
HY-101368A
Quantity:
MCE Japan Authorized Agent: