Isamoltan hydrochloride
Isamoltan ((±)-Isamoltane) hydrochloride is a selective antagonist of 5-HT1B receptor, with an IC50 of 39 nM for inhibits the binding of [125I]ICYP to 5-HT1B recognition sites in rat brain membranes. Isamoltan hydrochloride is also a β-adrenoceptor ligand, with an IC50 of 8.4 nM. Isamoltan hydrochloride shows anxiolytic activity.
For research use only. We do not sell to patients.
- CAS No.: 99740-06-4
- Formula: C16H23ClN2O2
- Molecular Weight:310.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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β-adrenoceptor 8.4 nM (IC50) |
5-HT5B Receptor 39 nM (IC50) |
Chemical Information
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CAS No. 99740-06-4
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Molecular Weight 310.82
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Formula C16H23ClN2O2
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SMILES
OC(COC1=CC=CC=C1N2C=CC=C2)CNC(C)C.Cl
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Synonyms
(±)-Isamoltane hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Waldmeier PC, et, al. Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jun; 337(6): 609-20. [Content Brief]
[2]. Rényi L, et, al. Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jan;343(1):1-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isamoltan hydrochloride Related Classifications
HY-19578A Related Classifications
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