99740-06-4
Chemical Structure
Isamoltan hydrochloride
Synonym(s): (±)-Isamoltane hydrochloride
- CAS No.: 99740-06-4
- Formula:C16H23ClN2O2
- Molecular Weight:310.82
IUPAC Name: 1-(2-(1H-pyrrol-1-yl)phenoxy)-3-(isopropylamino)propan-2-ol hydrochloride
InChIKey: DCOXRJZVVPMXLY-UHFFFAOYSA-N
SMILES: OC(COC1=CC=CC=C1N2C=CC=C2)CNC(C)C.Cl
Biological Activity: Isamoltan ((±)-Isamoltane) hydrochloride is a selective antagonist of 5-HT1B receptor, with an IC50 of 39 nM for inhibits the binding of [125I]ICYP to 5-HT1B recognition sites in rat brain membranes. Isamoltan hydrochloride is also a β-adrenoceptor ligand, with an IC50 of 8.4 nM. Isamoltan hydrochloride shows anxiolytic activity[1].
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Isamoltan hydrochloride | Isamoltan ((±)-Isamoltane) hydrochloride is a selective antagonist of 5-HT1B receptor, with an IC50 of 39 nM for inhibits the binding of [125I]ICYP to 5-HT1B recognition sites in rat brain membranes. Isamoltan hydrochloride is also a β-adrenoceptor ligand, with an IC50 of 8.4 nM. Isamoltan hydrochloride shows anxiolytic activity. | |||||||||||||||||||||
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Keywords
