Ro 31-8220 mesylate (Standard) (Synonyms: Ro 31-8220 methanesulfonate (Standard); Bisindolylmaleimide IX mesylate (Standard))

製品番号: HY-13866R 純度: 95%: 取扱説明書
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Ro 31-8220 mesylate (Standard) is the analytical standard of Ro 31-8220 mesylate (HY-13866). This product is intended for research and analytical applications. Ro 31-8220 mesylate is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC.

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Ro 31-8220 mesylate (Standard) 構造式

CAS 番号 : 138489-18-6

容量	価格（税別）	在庫状況	数量
5 mg	$306	お問い合わせ 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks	Estimated Time of Arrival: December 31
10 mg	$460	お問い合わせ 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks	Estimated Time of Arrival: December 31
25 mg	$760	お問い合わせ 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks	Estimated Time of Arrival: December 31
50 mg	$1064	お問い合わせ 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks	Estimated Time of Arrival: December 31
100 mg	$1490	お問い合わせ 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of Ro 31-8220 mesylate (Standard):

Ro 31-8220 formic 在庫あり

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純度とドキュメンテーション
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製品説明	Ro 31-8220 mesylate (Standard) is the analytical standard of Ro 31-8220 mesylate (HY-13866). This product is intended for research and analytical applications. Ro 31-8220 mesylate is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC.
Application	The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
分子量	553.65
分子式	C₂₆H₂₇N₅O₅S₂
CAS 番号	138489-18-6
SMILES	NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O
輸送条件	Room temperature in continental US; may vary elsewhere.
保管条件	Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション	取扱説明書 (2659 KB)

Ro 31-8220 mesylate (Standard) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 31-8220 mesylate (Standard)138489-18-6Ro 31-8220 methanesulfonate (Standard) Bisindolylmaleimide IX mesylate (Standard)PKCJNKReference StandardsProtein kinase Cc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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Ro 31-8220 mesylate (Standard) (Synonyms: Ro 31-8220 methanesulfonate (Standard); Bisindolylmaleimide IX mesylate (Standard))

Other Forms of Ro 31-8220 mesylate (Standard):

Product Information

純度とドキュメンテーション

カスタマーレビュー