Copy Link Print Information

Entacapone sodium salt

8 Cited Publications
Customer Review

Based on 8 publication(s) in Google Scholar

Entacapone sodium salt is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone sodium salt inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone sodium salt is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 µM). Entacapone sodium salt can be used for the research of Parkinson's disease. Entacapone sodium salt serves as as a inhibit of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.

For research use only. We do not sell to patients.

  • CAS No.: 1047659-02-8
  • Formula: C14H14N3NaO5
  • Molecular Weight:327.27
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Entacapone sodium salt Chemical Structure
    Entacapone sodium salt Chemical Structure
  • Experimental Validation Results for Entacapone sodium salt
  • Experimental Validation Results for Entacapone sodium salt
  • Experimental Validation Results for Entacapone sodium salt
  • Experimental Validation Results for Entacapone sodium salt
  • Experimental Validation Results for Entacapone sodium salt
  • Experimental Validation Results for Entacapone sodium salt
CAS No.: 1047659-02-8
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Entacapone sodium salt:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Purity & Documentation
  • References
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Entacapone sodium salt

More
Customer Validation & Images
Bio/Physico-chemical AssayFlow CytometryIFIn Vivo Efficacy Study
  • Bio/Physico-chemical Assay
  • Flow Cytometry
  • IF
  • Bio/Physico-chemical Assay
  • In Vivo Efficacy Study
  • In Vivo Efficacy Study
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Entacapone sodium salt Chemical Structure
    Entacapone sodium salt Chemical Structure
    1/16
  • 1/16

    Entacapone sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2024 Nov 4;84(21):3640-3656. [Abstract]

    Customer Validation
     The rate of NADH to NAD+ conversion rate measuring the mitochondrial complex I activity using mitochondrial extracts from U87 cells treated with DMSO, 50 μmol/L Entacapone, or 100 μmol/L Tolcapone for 24 hours.

  • 1/16

    Entacapone sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2024 Nov 4;84(21):3640-3656. [Abstract]

    Customer Validation
     ROS flow cytometry assay comparing the ROS production of U87 cells treated with DMSO (control) or 50 μmol/L Entacapone for 24 hours.

  • 1/16

    Entacapone sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2024 Nov 4;84(21):3640-3656. [Abstract]

    Customer Validation
     Immunofluorescence showing the localization of the mitochondria (as detected by HSP60) and dsRNA (as detected by J2) in the cytoplasm of VC, COMT-KO, Act-D–treated VC, Act-D–treated COMT-KO U87 cells (top), and wild-type U87 cells treated with DMSO or 50 µmol/L Entacapone for 24 hours (bottom).

  • 1/16

    Entacapone sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2024 Nov 4;84(21):3640-3656. [Abstract]

    Customer Validation
     Quantification of the percentage of macrophages that phagocytosed CT2A cells treated with DMSO, 50 µmol/L Entacapone, or 50 µmol/L Tolcapone. CT2A cells were pretreated with COMT inhibitors for 24 hours prior to coculturing with macrophages.

  • 1/16

    Entacapone sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2024 Nov 4;84(21):3640-3656. [Abstract]

    Customer Validation
     The drug treatment and irradiation schedule in mice bearing subcutaneous CT2A tumors. Vehicle and 30 mg/kg Entacapone were administered intraperitoneally daily from day 3 to day 35. The tumor-bearing right flank was irradiated on day 10 post tumor cell inoculation. IP, intraperitoneal injection; q.d., every day; IR, irradiation.

  • 1/16

    Entacapone sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2024 Nov 4;84(21):3640-3656. [Abstract]

    Customer Validation
     Tumor growth of C57BL/6 mice (n = 6) subcutaneously implanted with 5 × 105 CT2A cells and received Entacapone and Radiotherapy treatments.

  • Entacapone sodium salt