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4-trans-Hydroxy-glibenclamide

(別名: 4-trans-hydroxycyclohexyl Glyburide; 4-trans-hydroxy Glibenclamide)
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rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.

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  • 純度: 98.59%
  • CAS 番号: 23155-00-2
  • 分子式: C23H28ClN3O6S
  • 分子量:510.00
  • 保管条件:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 4-trans-Hydroxy-glibenclamide Chemical Structure
    4-trans-Hydroxy-glibenclamide 構造式
CAS 番号: 23155-00-2
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  • 4-trans-Hydroxy-glibenclamide Chemical Structure
    4-trans-Hydroxy-glibenclamide Chemical Structure
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  • 4-trans-Hydroxy-glibenclamide