23155-00-2
Chemical Structure
4-trans-Hydroxy-glibenclamide
Synonym(s): 4-trans-hydroxycyclohexyl Glyburide; 4-trans-hydroxy Glibenclamide
- CAS No.: 23155-00-2
- Formula:C23H28ClN3O6S
- Molecular Weight:510.00
IUPAC Name: 5-chloro-N-(4-(N-(((1r,4r)-4-hydroxycyclohexyl)carbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide
InChIKey: IUWSGCQEWOOQDN-IYARVYRRSA-N
SMILES: O=C(NCCC1=CC=C(S(=O)(NC(N[C@H]2CC[C@H](O)CC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC
Biological Activity: rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-trans-Hydroxy-glibenclamide | 98.59% | rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively. | ||||||||||||||||||||
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4-trans-Hydroxy glibenclamide-13C,d4 | 4-trans-Hydroxy glibenclamide-13C,d4 is 13C and deuterated labeled 4-trans-Hydroxy glibenclamide. | |||||||||||||||||||||
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4-trans-Hydroxy glibenclamide-d5 | 4-trans-Hydroxy glibenclamide-d5 is deuterated labeled 4-trans-Hydroxy glibenclamide. | |||||||||||||||||||||
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