NAS-181

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NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an K_i value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.

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NAS-181 Chemical Structure

CAS No. : 205242-62-2

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Other In-stock Forms of NAS-181:

Other Forms of NAS-181:

NAS-181 dimesylate In-stock

1 Publications Citing Use of MCE NAS-181

•Nat Neurosci. 2022 Dec;25(12):1651-1663. [Abstract]

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

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Purity & Documentation
References
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Description

NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an K_i value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions^[1].

In Vitro

NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices^[1].
NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[1]
Dosage:	20 mg/kg
Administration:	S.c.
Result:	Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40−60%).

Molecular Weight

442.53

Formula

C₂₀H₃₀N₂O₇S

CAS No.

205242-62-2

SMILES

CS(=O)(O)=O.[C@H]1(COC2=C3C(C=C(CN4CCOCC4)CO3)=CC=C2)CNCCO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Berg S, et al. (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist. J Med Chem. 1998 May 21;41(11):1934-42. [Content Brief]

NAS-181 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAS-181205242-62-2NAS181NAS 1815-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HTP accumulationbrain regionswet dog shakesp-chlorophenylalanineInhibitorinhibitorinhibit

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