Clenbuterol hydrochloride
Based on 6 publication(s) in Google Scholar
Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 21898-19-1
- Formula: C12H19Cl3N2O
- Molecular Weight:313.65
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocol
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Clenbuterol hydrochloride
MoreAll Adrenergic Receptor Isoforms
More
Biological Activity
Clenbuterol increases lipolysis in rat primary adipocytes compared with control. Free glycerol release into the culture medium is 158% and 190% of control values in cultures containing 0.1, or 1 μM Clenbuterol, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 21898-19-1
-
Appearance Solid
-
Molecular Weight 313.65
-
Formula C12H19Cl3N2O
-
Color White to off-white
-
SMILES
OC(CNC(C)(C)C)C1=CC(Cl)=C(N)C(Cl)=C1.[H]Cl
-
Synonyms
NAB-365 hydrochloride
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. [Abstract]2020 Sep 25;11(1):4857. PMID: 32978402 -
Adv Sci (Weinh)
Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury. [Abstract]2025 Oct 17:e03966. PMID: 41103249 -
Adv Sci (Weinh)
2021 Dec;8(24):e2100808. PMID: 34719888 -
Cell Rep
2025 Sep 23;44(10):116337. PMID: 40991929 -
Toxicol In Vitro
Development of 3D-QSAR models for predicting the activities of chemicals to stimulate muscle growth via β2-adrenoceptor. [Abstract]2021 Dec:77:105251. PMID: 34601065 -
Solvent & Solubility
DMSO : 83.33 mg/mL (265.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
MTS assay is performed to determine the number of viable cells in culture. Cells are treated with 0 (vehicle only), 0.1, or 1 μM Clenbuterol for 6, 12, 24, or 48 h. The absorbance is measured at 490 nm in a plate reader determine the formazan concentration, which is proportional to the number of living cells in culture[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Rats:
Rats are randomly divided into two treatment groups. The control group is provided with standard chow and water ad libitum for 3 weeks, while the Clenbuterol group is provided with standard chow and treated for 3 weeks with Clenbuterol administered via the drinking water (30 mg Clenbuterol/L). Body weight and the amount of water consumed are recorded twice each week. After 3 wk, the animals are anesthetized and hindlimb muscles are excised[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Handling Instructions (2659 KB)
References
[1]. O'Donnell JM, et al. Effects of clenbuterol and antidepressant drugs on beta adrenergic receptor/N-protein coupling in the cerebral cortex of the rat.J PharmacolExpTher. 1985 Jul;234(1):30-6. [Content Brief]
[2]. Culmsee C, Stumm RK, Schäfer MK, Weihe E, Krieglstein J. Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage. Eur J Pharmacol. 1999;379(1):33-45. [Content Brief]
[3]. Kim J, t al. The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility. Proc Natl Acad Sci U S A. 2020;117(22):12435-12443. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1883 mL | 15.9413 mL | 31.8827 mL | 79.7067 mL |
| 5 mM | 0.6377 mL | 3.1883 mL | 6.3765 mL | 15.9413 mL | |
| 10 mM | 0.3188 mL | 1.5941 mL | 3.1883 mL | 7.9707 mL | |
| 15 mM | 0.2126 mL | 1.0628 mL | 2.1255 mL | 5.3138 mL | |
| 20 mM | 0.1594 mL | 0.7971 mL | 1.5941 mL | 3.9853 mL | |
| 25 mM | 0.1275 mL | 0.6377 mL | 1.2753 mL | 3.1883 mL | |
| 30 mM | 0.1063 mL | 0.5314 mL | 1.0628 mL | 2.6569 mL | |
| 40 mM | 0.0797 mL | 0.3985 mL | 0.7971 mL | 1.9927 mL | |
| 50 mM | 0.0638 mL | 0.3188 mL | 0.6377 mL | 1.5941 mL | |
| 60 mM | 0.0531 mL | 0.2657 mL | 0.5314 mL | 1.3284 mL | |
| 80 mM | 0.0399 mL | 0.1993 mL | 0.3985 mL | 0.9963 mL | |
| 100 mM | 0.0319 mL | 0.1594 mL | 0.3188 mL | 0.7971 mL |
Clenbuterol hydrochloride Related Classifications
HY-B1614 Related Classifications
Powered by Bioz