1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Fenoterol hydrobromide

Fenoterol hydrobromide (Synonyms: Th-1165a; Phenoterol hydrobromide)

Cat. No.: HY-B0976A Purity: 98.40%
Handling Instructions

Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research.

For research use only. We do not sell to patients.

Fenoterol hydrobromide Chemical Structure

Fenoterol hydrobromide Chemical Structure

CAS No. : 1944-12-3

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Solution
10 mM * 1 mL in DMSO USD 93 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

In Vitro

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK[2].
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells[2].
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: THP-1 cells stimulated with AICAR
Concentration: 1 μM
Incubation Time: Pre-incubated 30 minutes
Result: Significantly downregulated the elevated phosphorylation levels of AMPK.
In Vivo

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6 weeks old) with neuropathy[3]
Dosage: 0.7 mg/kg
Administration: Intraperitoneal injection; twice a day; for 3 weeks
Result: Alleviated neuropathic allodynia during chronic treatment.
Clinical Trial
Molecular Weight

384.26

Formula

C₁₇H₂₂BrNO₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (260.24 mM)

H2O : 25 mg/mL (65.06 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6024 mL 13.0120 mL 26.0240 mL
5 mM 0.5205 mL 2.6024 mL 5.2048 mL
10 mM 0.2602 mL 1.3012 mL 2.6024 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 60 mg/mL (156.14 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.71%

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Fenoterol hydrobromide
Cat. No.:
HY-B0976A
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