2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Fenoterol

Fenoterol  (Synonyms: Th-1165; Phenoterol)

Cat. No.: HY-B0976 Purity: 99.08%
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Fenoterol (Th-1165), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research.

For research use only. We do not sell to patients.

Fenoterol Chemical Structure

Fenoterol Chemical Structure

CAS No. : 13392-18-2

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10 mg USD 130 In-stock
25 mg USD 270 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Fenoterol Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fenoterol (Th-1165), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

In Vitro

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK[2].
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells[2].
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fenoterol Related Antibodies

Western Blot Analysis[2]

Cell Line: THP-1 cells stimulated with AICAR
Concentration: 1 μM
Incubation Time: Pre-incubated 30 minutes
Result: Significantly downregulated the elevated phosphorylation levels of AMPK.
In Vivo

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6 weeks old) with neuropathy[3]
Dosage: 0.7 mg/kg
Administration: Intraperitoneal injection; twice a day; for 3 weeks
Result: Alleviated neuropathic allodynia during chronic treatment.
Clinical Trial
Molecular Weight

303.35

Appearance

Solid

Formula

C17H21NO4
CAS No.
SMILES

OC1=CC(C(O)CNC(C)CC2=CC=C(O)C=C2)=CC(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (329.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2965 mL 16.4826 mL 32.9652 mL
5 mM 0.6593 mL 3.2965 mL 6.5930 mL
10 mM 0.3297 mL 1.6483 mL 3.2965 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.24 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Fenoterol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fenoterol13392-18-2Th-1165 PhenoterolTh1165Th 1165Adrenergic ReceptorBeta Receptorβ2-adrenoceptorsympathomimeticbronchodilatorantiallergicanti-inflammatoryexosomeInhibitorinhibitorinhibit

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