2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. Adrenergic Receptor Apoptosis
  4. Metoprolol tartrate

Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties.

For research use only. We do not sell to patients.

CAS No. : 56392-17-7

Size Price Stock Quantity
Free Sample (0.1 - 0.2 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg In-stock
500 mg In-stock
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 15 publication(s) in Google Scholar

Other Forms of Metoprolol tartrate:

Metoprolol tartrate Related Antibodies

Top Publications Citing Use of Products

    Metoprolol tartrate purchased from MedChemExpress. Usage Cited in: J Intern Med. 2024 Sep;296(3):291-297.  [Abstract]

    Selective blockers Metoprolol (METO; β1-AR blocker; 10 µmol/L) and ICI118551 (ICI; β2-AR blocker; 10 µmol/L) were used to explore the interactions of the spike protein with β1-AR and β2-AR, respectively.

    Metoprolol tartrate purchased from MedChemExpress. Usage Cited in: J Intern Med. 2024 Sep;296(3):291-297.  [Abstract]

    cAMP accumulation in NMCMs treated with ISO (1 µmol/L) and the spike trimer (10 nmol/L) with or without pretreatment with Metoprolol (10 µmol/L) and ICI118551 (10 µmol/L).

    Metoprolol tartrate purchased from MedChemExpress. Usage Cited in: SSRN. 2024 May 30.

    Quantification of immunofluorescence staining of phosphorylated-GSK3β in NRCFs. The ratio of phosphorylated protein to total protein reflects the activation of signaling pathways. NRCFs were starved for 24h. Mig and Metoprolol (Met: 10 μM) were added ahead for 1h, then ISO was added for 24h. Met was used as positive control.

    View All Adrenergic Receptor Isoform Specific Products:

    View All Isoforms
    α adrenergic receptor β adrenergic receptor

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3].

    IC50 & Target

    β1 adrenoceptor

     

    In Vitro

    Metoprolol (0-1000 μg/mL; 24-72 h) shows cytotoxic effect on U937 and MOLT-4 cells dose and time dependently[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Metoprolol tartrate Related Antibodies

    Cell Cytotoxicity Assay[3]

    Cell Line: U937 and MOLT-4 cells
    Concentration: 1, 10, 50, 100, 500 and 1000 μg/mL
    Incubation Time: 24, 48 and 72 h
    Result: Significantly decreased the viability of U937 and MOLT-4 cells at 1000 μg/mL (3740.14µM) concentration after 48 hours incubation time, significantly reduced the viability of U937 cells at ≥500 μg/ml (≥1870.07µM) concentrations after 72 hours incubation time, and significantly decreased the viability of MOLT4 cells at ≥100 μg/ml (≥374.01µM) concentrations after 72 hours incubation.
    In Vivo

    Metoprolol (2.5 mg/kg/h; infusion; 11 weeks) reduces proinflammatory cytokines and atherosclerosis in ApoE−/− Mice[1].
    Metoprolol (15 mg/kg/q12h; i.g.; 5 days) shows anti-inflammation and anti-virus effects in murine model with coxsackievirus B3-induced viral myocarditis[2].
    Metoprolol (2.5 mg/kg; i.v.; 3 bolus injections) significantly decreased activated caspase-9 protein expression and inhibits myocardial apoptosis in coronary microembolization (CME) rats[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male ApoE−/− mice[1]
    Dosage: 2.5 mg/kg/h
    Administration: Via osmotic minipumps, 11 weeks
    Result: Significantly reduced atherosclerotic plaque area in thoracic aorta, reduced serum TNFα and the chemokine CXCL1 as well as decreasing the macrophage content in the plaques.
    Animal Model: Balb/c mice, coxsackievirus B3 (CVB3) induced viral myocarditis (VMC) model[2]
    Dosage: 15 mg/kg/q12h
    Administration: Oral gavage, 5 consecutive days
    Result: Reduced pathological scores of VMC induced by CVB3 infection, protected the myocardium against viral damage by reducing serum cTn-I levels. Decreased the levels of myocardial pro-inflammatory cytokines and increase the expression of anti-inflammatory cytokine. Significantly decreased myocardial virus titers.
    Molecular Weight

    342.41

    Formula

    C19H31NO9
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    OC(CNC(C)C)COC1=CC=C(CCOC)C=C1.O=C(O)[C@H](O)[C@@H](O)C(O)=O.[0.5]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (292.05 mM; Need ultrasonic)

    DMSO : 70 mg/mL (204.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9205 mL 14.6024 mL 29.2048 mL
    5 mM 0.5841 mL 2.9205 mL 5.8410 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.98%

    SDS (623 KB)

    COA (251 KB) HNMR (254 KB) LCMS (95 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.9205 mL 14.6024 mL 29.2048 mL 73.0119 mL
    5 mM 0.5841 mL 2.9205 mL 5.8410 mL 14.6024 mL
    10 mM 0.2920 mL 1.4602 mL 2.9205 mL 7.3012 mL
    15 mM 0.1947 mL 0.9735 mL 1.9470 mL 4.8675 mL
    20 mM 0.1460 mL 0.7301 mL 1.4602 mL 3.6506 mL
    25 mM 0.1168 mL 0.5841 mL 1.1682 mL 2.9205 mL
    30 mM 0.0973 mL 0.4867 mL 0.9735 mL 2.4337 mL
    40 mM 0.0730 mL 0.3651 mL 0.7301 mL 1.8253 mL
    50 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4602 mL
    60 mM 0.0487 mL 0.2434 mL 0.4867 mL 1.2169 mL
    80 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9126 mL
    100 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Metoprolol tartrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Metoprolol56392-17-7Adrenergic ReceptorApoptosisBeta Receptorhypertensionischaemic heart diseaseanginaanti-inflammationanti-virusprostate cancerbreast cancerInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Metoprolol tartrate
    Cat. No.:
    HY-17503B
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (623 KB) Français - FR (623 KB) Deutsch - DE (623 KB) Norwegian - NO (623 KB) Español - ES (623 KB) Swedish - SV (623 KB) Italian - IT (623 KB) Korean - KR (623 KB) Portuguese - PT (623 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.