1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Isocarboxazid

Isocarboxazid 

Cat. No.: HY-13929 Purity: >98.0%
Handling Instructions

Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro.

For research use only. We do not sell to patients.

Isocarboxazid Chemical Structure

Isocarboxazid Chemical Structure

CAS No. : 59-63-2

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10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro[1].

IC50 & Target

IC50: 4.8 μM (rat brain monoamine oxidase)[1].

In Vivo

Isocarboxazid (1, 3 mg/kg, i.p., 60 min) pretreatment in mice shows the significant increased number of head twitches at 15 and 30 min after 5-HTP[2].
Isocarboxazid (1, 3 mg/kg, i.p., 60 min) treatment in mice together with 5-HTP administration causes 43% 5-HT concentration increased and 22% of 5-HIAA decreased compared to brain concentrations in mice given 5-HTP alone[2].

Animal Model: Twelve male mice of dd strain (20-25 g)[2]
Dosage: 0, 0.3,1, 3 mg/kg
Administration: Intraperitoneally 60 min before intravenous injection of 5-HTP
Result: The number of head twitches at 15 and 30 min after 5-HTP was increased.
43% 5-HT concentration increased and 22% of 5-HIAA decreased.
Clinical Trial
Molecular Weight

231.25

Formula

C₁₂H₁₃N₃O₂

CAS No.

59-63-2

SMILES

O=C(C1=NOC(C)=C1)NNCC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Isocarboxazid
Cat. No.:
HY-13929
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