6-Chloroguanineriboside
Based on 1 Customer Validation
6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analog. 6-Chloroguanineriboside has extremely low affinity for guanosine binding sites in rat brain (Ki: 253.1 μM).
For research use only. We do not sell to patients.
- Purity: 98.02%
- CAS No.: 2004-07-1
- Formula: C10H12ClN5O4
- Molecular Weight:301.69
-
Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Anti-Aging Compound Library
HY-L034
-
Covalent Screening Library
HY-L036
-
Reprogramming Compound Library
HY-L039
-
Nucleotide Compound Library
HY-L044
-
Anti-Lung Cancer Compound Library
HY-L075
-
Anti-Blood Cancer Compound Library
HY-L079
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Anti-Hematopathy Compound Library
HY-L171
-
MCE Bioactive Compound Library
HY-L001V
-
Covalent Screening Library Plus
HY-L036P
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
>300 μM
Compound: 5
|
Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
|
[PMID: 17336519] |
6-Chloroguanineriboside derivatives exhibit significant inhibitory activity against ADP (HY-W010918)- and collagen (HY-NP003)-induced platelet aggregation and adhesion in rabbits[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2004-07-1
-
Appearance Solid
-
Molecular Weight 301.69
-
Formula C10H12ClN5O4
-
Color White to off-white
-
SMILES
O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)N=C3Cl)=C3N=C2)O[C@@H]1CO
-
Synonyms
6-Chloroguanosine
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (331.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
[1]. Traversa U, et al. Rat brain guanosine binding site. Biological studies and pseudo-receptor construction. Bioorg Med Chem. 2003 Dec 1;11(24):5417-25. [Content Brief]
[2]. Kikugawa K, et al. Platelet aggregation inhibitors. 2. Inhibition of platelet aggregation by 5'-, 2-, 6-, and 8-substituted adenosines. J Med Chem. 1972 Apr;15(4):387-90. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3147 mL | 16.5733 mL | 33.1466 mL | 82.8665 mL |
| 5 mM | 0.6629 mL | 3.3147 mL | 6.6293 mL | 16.5733 mL | |
| 10 mM | 0.3315 mL | 1.6573 mL | 3.3147 mL | 8.2867 mL | |
| 15 mM | 0.2210 mL | 1.1049 mL | 2.2098 mL | 5.5244 mL | |
| 20 mM | 0.1657 mL | 0.8287 mL | 1.6573 mL | 4.1433 mL | |
| 25 mM | 0.1326 mL | 0.6629 mL | 1.3259 mL | 3.3147 mL | |
| 30 mM | 0.1105 mL | 0.5524 mL | 1.1049 mL | 2.7622 mL | |
| 40 mM | 0.0829 mL | 0.4143 mL | 0.8287 mL | 2.0717 mL | |
| 50 mM | 0.0663 mL | 0.3315 mL | 0.6629 mL | 1.6573 mL | |
| 60 mM | 0.0552 mL | 0.2762 mL | 0.5524 mL | 1.3811 mL | |
| 80 mM | 0.0414 mL | 0.2072 mL | 0.4143 mL | 1.0358 mL | |
| 100 mM | 0.0331 mL | 0.1657 mL | 0.3315 mL | 0.8287 mL |
6-Chloroguanineriboside Related Classifications
HY-W009234 Related Classifications
Powered by Bioz