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Results for "

progesterone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Progesterone Receptor (111) 17β-HSD (1) 3β-HSD (2) Akt (1) Aldose Reductase (2) Androgen Receptor (16) Angiotensin Receptor (1) Antibiotic (2) Apoptosis (8) Autophagy (14) Bacterial (4) Bcl-2 Family (2) Biochemical Assay Reagents (5) c-Myc (1) Calcium Channel (2) Caspase (2) CDK (2) Cytochrome P450 (9) Dengue Virus (2) Dopamine β-hydroxylase (1) Drug Derivative (8) Drug Intermediate (7) Drug Isomer (1) Drug Metabolite (6) EGFR (1) Endogenous Metabolite (30) Estrogen Receptor/ERR (16) Ferroptosis (1) FKBP (3) Flavivirus (2) Fluorescent Dye (2) Fungal (1) GABA Receptor (2) Glucocorticoid Receptor (21) Glutathione Peroxidase (1) Glycosyltransferase (1) GnRH Receptor (6) GSK-3 (1) Heme Oxygenase (HO) (1) HIV (4) IFNAR (2) Insecticide (1) Isotope-Labeled Compounds (33) JNK (1) MDM-2/p53 (1) Melanocortin Receptor (1) Mineralocorticoid Receptor (10) Neurokinin Receptor (3) Neuropeptide FF Receptor (1) NF-κB (1) NO Synthase (5) Oxytocin Receptor (1) p38 MAPK (1) Parasite (1) PARP (1) PERK (1) Phosphatase (1) Phosphodiesterase (PDE) (1) PPAR (1) Prostaglandin Receptor (1) PROTACs (2) Reactive Oxygen Species (ROS) (7) Reference Standards (36) Sigma Receptor (1) Steroid Sulfatase (1) Survivin (2) Topoisomerase (1) UGT (1)
By Research Areas:	Cancer (86) Cardiovascular Disease (23) Endocrinology (100) Infection (13) Inflammation/Immunology (18) Metabolic Disease (44) Neurological Disease (22)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (8)

223

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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Progesterone Receptor

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-N0437

*Progesterone* 30+ Cited Publications Pregn-4-ene-3,20-dione	Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Infection Neurological Disease Cancer
Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-13683

Mifepristone Maximum Cited Publications 71 Publications Verification RU486; RU 38486	Endogenous Metabolite Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy	Endocrinology Cancer
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay .

HY-B0469

Medroxyprogesterone acetate Maximum Cited Publications 35 Publications Verification Medroxyprogesterone 17-acetate; Farlutin	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Cancer
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with *progesterone, androgen* and glucocorticoid receptors .

HY-N0376

Liquiritin 10+ Cited Publications	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-134124

Glutathione ethyl ester	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-107850

Pregnanediol NSC 1612; NSC 47462	Drug Metabolite UGT	Cardiovascular Disease Metabolic Disease
Pregnanediol (NSC 1612) is a Progesterone (HY-N0437) metabolite. Pregnanediol does not affect the transcriptional activity of UGT1A1 enhancer-promoter complex of WT and variant type. pregnanediol inhibits glucuronidation activity of G71R-UGT1A1. Pregnanediol is a cause of breast milk jaundice in carriers of G71R .

HY-B0257A

Dydrogesterone 2 Publications Verification	Progesterone Receptor	Endocrinology
Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.

HY-N0437R

Progesterone (Standard) 30+ Cited Publications Pregn-4-ene-3,20-dione (Standard)	Reference Standards Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone (Standard) is the analytical standard of Progesterone. This product is intended for research and analytical applications. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-W040047

Pregnanediol 3-glucuronide	Endogenous Metabolite	Metabolic Disease
Pregnanediol 3-glucuronide is the main terminal metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is the metabolite of Progesterone produced in the liver through hydroxylation and glucuronidation, with high hydrophilicity and easy excretion through urine. A decrease in the level of Pregnanediol 3-glucuronide is associated with an increased risk of thyroid cancer, while an increase is associated with the state of pregnancy. Pregnanediol 3-glucuronide is of great significance in the monitoring of female reproductive health, pregnancy assessment, and the diagnosis of endocrine diseases .

HY-P2232

Conalbumin Ovotransferrin	Bacterial	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Conalbumin (Ovotransferrin) is an iron-binding protein present in egg white with antibacterial activity. Conalbumin can also be used to induce bronchial asthma. Conalbumin exhibits induced mRNA accumulation in chicken oviduct cells by estrogen and progesterone .

HY-N0437S

Progesterone-d9 Pregn-4-ene-3,20-dione-d₉	Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone-d₉ is the deuterium labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-119384

Promegestone 1 Publications Verification R-5020; Surgestone	Progesterone Receptor	Endocrinology Cancer
Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research .

HY-B0648

Medroxyprogesterone 5+ Cited Publications 17α-Hydroxy-6α-methylprogesterone; U8840	Progesterone Receptor	Endocrinology Cancer
Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) .

HY-B1095

Chlormadinone acetate 1 Publications Verification	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor GABA Receptor	Neurological Disease Metabolic Disease
Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-114009

AKR1C1-IN-1 2 Publications Verification	Aldose Reductase	Neurological Disease
AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a K_i value of 4 nM for AKR1C1 .

HY-B0742

Hydroxyprogesterone caproate 5+ Cited Publications 17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate	Progesterone Receptor	Endocrinology
Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

HY-111614

Melengestrol acetate	Progesterone Receptor	Metabolic Disease Cancer
Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity . Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research .

HY-W013172

Norgestimate	Progesterone Receptor	Endocrinology
Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive . Norgestimate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14959

Ulipristal CDB-3236; Deacetyl CDB-2914	Progesterone Receptor	Endocrinology Cancer
Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system .

HY-W011890

Cridanimod 1 Publications Verification	Progesterone Receptor IFNAR	Inflammation/Immunology Cancer
Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer .

HY-14234

Glucocorticoid receptor agonist 1 Publications Verification	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC₅₀ values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin .

HY-W006492

5a-Pregnane-3,20-dione 1 Publications Verification	Endogenous Metabolite	Endocrinology Cancer
5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-NP180

Progesterone/BSA	Calcium Channel	Metabolic Disease
Progesterone/BSA is a conjugate of Progesterone (HY-N0437) and bovine serum albumin (BSA). Progesterone/BSA cannot penetrate the plasma membrane of human sperm, but still rapidly elevates intracellular free calcium and induces the acrosome reaction. Progesterone/BSA can also act as a probe to specifically bind to progesterone-binding proteins on the membrane of rat brain synaptosomes .

HY-N11224

Pregnanetriol	Drug Metabolite Progesterone Receptor	Endocrinology
Pregnanetriol is a metabolite of 17α-Hydroxyprogesterone (HY-B0891). 17α-Hydroxyprogesterone is an endogenous progesterone .

HY-11028

PF-02413873 PF-2413873	Progesterone Receptor	Endocrinology
PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a K_i of 2.6 nM. PF-02413873 can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo .

HY-113020

21-Hydroxypregnenolone 1 Publications Verification	Endogenous Metabolite Cytochrome P450	Metabolic Disease
21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM .

HY-123352

ZK 216348 (+)-ZK 216348	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
ZK 216348 ((+)-ZK 216348) is a nonsteroidal selective glucocorticoid receptor agonist with an IC₅₀ of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC₅₀s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects .

HY-119433

Asoprisnil J867	Progesterone Receptor	Endocrinology
Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human .

HY-B2245

Estradiol dipropionate	Estrogen Receptor/ERR Progesterone Receptor	Endocrinology
Estradiol dipropionate is a combined estrogen-progesterone, acts as an estrogen and *progesterone* agonist .

HY-131654

16α-Hydroxy progesterone	Biochemical Assay Reagents	Others
16α-Hydroxy progesterone is a biochemical reagent.

HY-106389

Onapristone ZK 98299	Progesterone Receptor	Cancer
Onapristone is a progesterone receptor antagonist, with K_ds of 11.6 nM and 11.90 nM for human endometrium and myometrium progesterone receptor in saturation analysis. Onapristone has antitumor activity .

HY-107850S

Pregnanediol-d5 NSC 1612-d₅; NSC 47462-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Pregnanediol-d₅ is the deuterium labeled Pregnanediol. Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo .

HY-16775

Vilaprisan BAY 1002670	Progesterone Receptor	Cancer
Vilaprisan is a selective progesterone receptor modulator (SPRM), which targets progesterone receptors. Vilaprisan can inhibit cell proliferation and stimulate apoptosis. Vilaprisan has oral efficacy and anti-proliferative activity against uterine leiomyoma (UF ).

HY-B0469R

Medroxyprogesterone acetate (Standard) Maximum Cited Publications 35 Publications Verification Medroxyprogesterone 17-acetate(Standard); Farlutin (Standard)	Reference Standards Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Cancer
Medroxyprogesterone acetate (Standard) is the analytical standard of Medroxyprogesterone acetate. This product is intended for research and analytical applications. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with *progesterone, androgen* and glucocorticoid receptors .

HY-W102516

6-Dehydroprogesterone Δ6-progesterone	Endogenous Metabolite	Others
6-Dehydroprogesterone (Δ6-Progesterone) is a steroid compound that can be found in Botryodiplodia theobromae. 6-Dehydroprogesterone is a metabolic product of Progesterone (HY-N0437) after a microbial dehydrogenation reaction. 6-Dehydroprogesterone can be used to study steroid metabolism pathways, microbial dehydrogenase activity, and the biotransformation of steroids .

HY-N0437S2

Progesterone-13C3 1 Publications Verification Pregn-4-ene-3,20-dione-¹³C₃	Isotope-Labeled Compounds Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone- ¹³C₃ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-17649

EIDD-036	Progesterone Receptor	Neurological Disease
EIDD-036, is the blood-brain barrier penetrant C-20 oxime of Progesterone (HY-N0437), that binds progesterone receptor (PR) with an IC₅₀ of 171 nM. EIDD-036 is the active metabolite of EIDD-1723 (HY-125547). EIDD-036 exhibits promising challenges for rapid administration in acute trauma. EIDD-036 can be used for the study of traumatic brain injury (TBI) .

HY-157493

PR antagonist 1	Progesterone Receptor	Endocrinology
PR antagonist 1 (compound 8) is a selective progesterone receptor (PR) antagonist, and can be used for the research of a variety of progesterone-related diseases and disorders such as endometriosis and uterine fibroids .

HY-B0742R

Hydroxyprogesterone caproate (Standard) 5+ Cited Publications 17α-Hydroxyprogesterone hexanoate(Standard); 17α-Hydroxyprogesterone caproate (Standard)	Reference Standards Progesterone Receptor	Others
Hydroxyprogesterone caproate (Standard) is the analytical standard of Hydroxyprogesterone caproate. This product is intended for research and analytical applications. Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

HY-105128

Epostane WIN 32729	3β-HSD	Endocrinology
Epostane (WIN 32729) is an orally active inhibitor for 3β-hydroxysteroid dehydrogenase, with IC₅₀ of 1.45 nM. Epostane blocks ovulation and pregnancy in rats .

HY-B0469S

Medroxyprogesterone acetate-d3 1 Publications Verification Medroxyprogesterone 17-acetate-d₃; Farlutin-d₃	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor	Endocrinology Cancer
Medroxyprogesterone acetate-d₃ is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-B0257AS

Dydrogesterone-D6	Progesterone Receptor	Endocrinology
Dydrogesterone-d₆ is the deuterium labeled Dydrogesterone. Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.

HY-125547

EIDD-1723	Progesterone Receptor	Neurological Disease Endocrinology
EIDD-1723 is a Progesterone (HY-N0437) analogues, that binds progesterone receptor (PR) with an IC₅₀ of 2.25 μM. EIDD-1723 is the prodrug of EIDD-036 (HY-17649). EIDD-1723 may exert its neuroprotective effects not solely through progesterone receptor (PR)-dependent pathways but also via non-genomic mechanisms, such as modulation of inflammatory responses and oxidative stress. EIDD-1723 can be used for the study of traumatic brain injury (TBI) .

HY-12073

WAY-255348	Progesterone Receptor	Endocrinology Cancer
W-255348 is an effective non-steroidal progesterone receptor (PR) antagonist that acquires antagonist activity by binding to and subsequently blocking progesterone induced nuclear accumulation, phosphorylation, and PR promoter interactions. WAY-255348 can be used in the research of reproductive disorders or PR-positive breast cancer .

HY-14247B

Fadrozole hydrochloride hemihydrate 2 Publications Verification CGS 16949A hemihydrate; (Rac)-FAD286 hydrochloride hemihydrate	Cytochrome P450	Endocrinology Cancer
Fadrozole hydrochloride hemihydrate is an orally active, potent, selective and nonsteroidal aromatase inhibitor, with an IC₅₀ of 6.4 nM. Fadrozole hydrochloride hemihydrate inhibits the production of estrogen and progesterone, with IC₅₀ values of 0.03 and 120 μM. Fadrozole hydrochloride hemihydrate shows prevention of spontaneous tumours. Fadrozole hydrochloride hemihydrate can be used for the research of estrogen-dependent disease and cancer .

HY-N7424

4,7-Dihydroxycoumarin 4,7-DHC	EGFR Estrogen Receptor/ERR Progesterone Receptor	Cancer
4,7-Dihydroxycoumarin is an EGFR inhibitor, estrogen receptor inhibitor, and progesterone receptor inhibitor. 4,7-Dihydroxycoumarin against breast cancer cells with an IC₅₀ velue of 18.36 μg/mL. 4,7-Dihydroxycoumarin can be used for the research of breast cancer .

HY-N3493

Isocupressic acid (+)-Isocupressic acid	Others	Others
Isocupressic acid ((+)-Isocupressic acid) is an abortifacient compound .

HY-N0437S3

Progesterone-13C2 Pregn-4-ene-3,20-dione-¹³C₂	Isotope-Labeled Compounds Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone- ¹³C₂ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-P10780

RFRP-3 (mouse) Neuropeptide NPVF (mouse)	Neuropeptide FF Receptor Apoptosis MDM-2/p53 PERK	Endocrinology
RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development .

HY-B0648S

Medroxyprogesterone-d3 17α-Hydroxy-6α-methylprogesterone-d₃; U8840-d₃	Progesterone Receptor	Endocrinology
Medroxyprogesterone-d₃ is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

Cat. No.	Nombre del producto

HY-L074

Anti-Breast Cancer Compound Library

3,232 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 3,232 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Cat. No.	Nombre del producto	Type

HY-175147

Progesterone 3-PEG11-biotin	Fluorescent Dyes
Progesterone 3-PEG11-biotin is an affinity probe. Progesterone 3-PEG11-biotin allows progesterone to be detected or immobilized using the biotin ligand.

HY-D2428

OVA-PEG-Cy3

Fluorescent Dyes

OVA-PEG-Cy3 is a Cy3 (HY-D0822)-labeled OVA-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Ovalbumins (OVA), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues .

Cat. No.	Nombre del producto	Type

HY-W250978

Ovalbumins

4 Publications Verification

Biochemical Assay Reagents

Ovalbumins (OVA), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues .
We recommend using Ovalbumin, low endotoxin (HY-W250978A) to establish an asthma model.

HY-P2232

Conalbumin Ovotransferrin	Biochemical Assay Reagents
Conalbumin (Ovotransferrin) is an iron-binding protein present in egg white with antibacterial activity. Conalbumin can also be used to induce bronchial asthma. Conalbumin exhibits induced mRNA accumulation in chicken oviduct cells by estrogen and progesterone .

HY-W250978A

Ovalbumin, low endotoxin

Biochemical Assay Reagents

Ovalbumin, low endotoxin (OVA, low endotoxin), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues . Ovalbumin, a low endotoxin, can be used to establish an asthma model .

HY-NP180

Progesterone/BSA	Biochemical Assay Reagents
Progesterone/BSA is a conjugate of Progesterone (HY-N0437) and bovine serum albumin (BSA). Progesterone/BSA cannot penetrate the plasma membrane of human sperm, but still rapidly elevates intracellular free calcium and induces the acrosome reaction. Progesterone/BSA can also act as a probe to specifically bind to progesterone-binding proteins on the membrane of rat brain synaptosomes .

HY-131654

16α-Hydroxy progesterone	Biochemical Assay Reagents
16α-Hydroxy progesterone is a biochemical reagent.

HY-W250316

Alpha-d-Glucopyranoside, beta-d-fructofuranosyl, octadecanoate Sucrose Stearate, Type II, USP	Biochemical Assay Reagents
Alpha-d-Glucopyranoside, beta-d-fructofuranosyl, octadecanoate (Sucrose Stearate, Type II, USP) is a non-ionic surfactant. Alpha-d-Glucopyranoside, beta-d-fructofuranosyl, octadecanoate enhances the skin permeability of formulations .

HY-NP186

Helix pomatia Agglutinin

Biochemical Assay Reagents

Helix pomatia Agglutinin is a N-acetylgalactosamine (GalNAc) binding lectin, found in the reproductive gland of a Roman snail. Helix pomatia Agglutinin binds with high affinity (k_D = 1.9-2.4 μM) steroid hormones: testosterone and progesterone. Helix pomatia Agglutinin interacts with adenine (k_D = 5.4 μM) and arylaminonaphthalene sulfonate TNS (k_D = 12 μM). Helix pomatia Agglutinin is commonly used for characterizing, imaging, or targeting glycoconjugates, and is also a very useful tool for glycomics analysis . Helix pomatia Agglutinin can be used for cancer prognosis study .

Cat. No.	Nombre del producto	Target	Research Area

HY-134124

Glutathione ethyl ester	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-P10780

RFRP-3 (mouse) Neuropeptide NPVF (mouse)	Neuropeptide FF Receptor Apoptosis MDM-2/p53 PERK	Endocrinology
RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development .

HY-P2424

Cholecystokinin-J CCK-J	Calcium Channel	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release .

HY-P2082

[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH	GnRH Receptor	Others
[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH is a gonadotropin-releasing hormone (Gn-RH) agonist that has a dose-dependent inhibitory activity on progesterone secretion from cultured human granulosa cells.

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N0437

*Progesterone* 30+ Cited Publications Pregn-4-ene-3,20-dione	Structural Classification Other disease Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Source Classification Cancer	Progesterone Receptor Endogenous Metabolite
Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-B0469

Medroxyprogesterone acetate Maximum Cited Publications 35 Publications Verification Medroxyprogesterone 17-acetate; Farlutin	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with *progesterone, androgen* and glucocorticoid receptors .

HY-N0376

Liquiritin 10+ Cited Publications	Monophenols Flavonoids Neurological Disease Classification of Application Fields Leguminosae Flavonones Phenols Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-107850

Pregnanediol NSC 1612; NSC 47462	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Drug Metabolite UGT
Pregnanediol (NSC 1612) is a Progesterone (HY-N0437) metabolite. Pregnanediol does not affect the transcriptional activity of UGT1A1 enhancer-promoter complex of WT and variant type. pregnanediol inhibits glucuronidation activity of G71R-UGT1A1. Pregnanediol is a cause of breast milk jaundice in carriers of G71R .

HY-N0437R

Progesterone (Standard) 30+ Cited Publications Pregn-4-ene-3,20-dione (Standard)	Other disease Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Reference Standards Progesterone Receptor Endogenous Metabolite
Progesterone (Standard) is the analytical standard of Progesterone. This product is intended for research and analytical applications. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-W040047

Pregnanediol 3-glucuronide	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
Pregnanediol 3-glucuronide is the main terminal metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is the metabolite of Progesterone produced in the liver through hydroxylation and glucuronidation, with high hydrophilicity and easy excretion through urine. A decrease in the level of Pregnanediol 3-glucuronide is associated with an increased risk of thyroid cancer, while an increase is associated with the state of pregnancy. Pregnanediol 3-glucuronide is of great significance in the monitoring of female reproductive health, pregnancy assessment, and the diagnosis of endocrine diseases .

HY-N10549

Gigantol 1 Publications Verification	Structural Classification Classification of Application Fields Orchidaceae Other Diseases Phenols Polyphenols Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .

HY-W006492

5a-Pregnane-3,20-dione 1 Publications Verification	Structural Classification Classification of Application Fields Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Endogenous Metabolite
5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-N11224

Pregnanetriol	Structural Classification Endogenous metabolite Steroids Source Classification	Drug Metabolite Progesterone Receptor
Pregnanetriol is a metabolite of 17α-Hydroxyprogesterone (HY-B0891). 17α-Hydroxyprogesterone is an endogenous progesterone .

HY-113020

21-Hydroxypregnenolone 1 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Cytochrome P450
21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM .

HY-113062

20α-Dihydroprogesterone 20-OH-P	Animals Steroids Source Classification	Endogenous Metabolite Cytochrome P450
20α-Dihydroprogesterone is the metabolite of Progesterone (HY-N0437). 20α-Dihydroprogesterone inhibits cell proliferation and migration in breast tissue. 20α-Dihydroprogesterone inhibits aromatase in cell MCF-7aro with IC₅₀ about 5 μM .

HY-B0469R

Medroxyprogesterone acetate (Standard) Maximum Cited Publications 35 Publications Verification Medroxyprogesterone 17-acetate(Standard); Farlutin (Standard)	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Reference Standards Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite
Medroxyprogesterone acetate (Standard) is the analytical standard of Medroxyprogesterone acetate. This product is intended for research and analytical applications. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with *progesterone, androgen* and glucocorticoid receptors .

HY-W102516

6-Dehydroprogesterone Δ6-progesterone	Endogenous metabolite Steroids Source Classification	Endogenous Metabolite
6-Dehydroprogesterone (Δ6-Progesterone) is a steroid compound that can be found in Botryodiplodia theobromae. 6-Dehydroprogesterone is a metabolic product of Progesterone (HY-N0437) after a microbial dehydrogenation reaction. 6-Dehydroprogesterone can be used to study steroid metabolism pathways, microbial dehydrogenase activity, and the biotransformation of steroids .

HY-N3493

Isocupressic acid (+)-Isocupressic acid	Pinaceae Pinus ponderosa Douglas ex C. Lawson Plants	Others
Isocupressic acid ((+)-Isocupressic acid) is an abortifacient compound .

HY-Z8245

20b-Dihydroprogesterone progesterone EP impurity C	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Drug Derivative
20b-Dihydroprogesterone (Compond III) is a C-21 steroid found in water beetles Cybister limbatus, C. tripunctatus and C. confuses .

HY-B0652R

Etonogestrel (Standard) 3-Oxodesogestrel (Standard); 3-keto-Desogestrel (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Drug Metabolite Reference Standards Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (Standard) is the analytical standard of Etonogestrel. This product is intended for research and analytical applications. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-107850R

Pregnanediol (Standard) NSC 1612 (Standard); NSC 47462 (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Endogenous Metabolite Reference Standards
Pregnanediol (Standard) is the analytical standard of Pregnanediol. This product is intended for research and analytical applications. Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo .

HY-N0376R

Liquiritin (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Flavonones Phenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Reactive Oxygen Species (ROS)
Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-W006492R

5a-Pregnane-3,20-dione (Standard)	Structural Classification Disease markers Nervous System Disorder Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-133056R

Pseudomonic acid C (Standard)	Microorganisms Source Classification	Reference Standards Antibiotic Bacterial
Algestone acetophenide (Standard) is the analytical standard of Algestone acetophenide. This product is intended for research and analytical applications. Algestone acetophenide is a progesterone drug. Algestone acetophenide can be used in combination with estrogen as a long-acting injectable contraceptive .

HY-109564

5α-Pregnane-3β,6α-diol-20-one	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Drug Metabolite
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

HY-113020R

21-Hydroxypregnenolone (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite Cytochrome P450
21-Hydroxypregnenolone (Standard) is the analytical standard of 21-Hydroxypregnenolone (HY-113020). This product is intended for research and analytical applications. 21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM.

HY-131586

3,7-Dihydroxyflavone Resogalangin	Flavonoids Flavones Plants Fabaceae Zuccagnia punctata Cav. Source Classification	17β-HSD Estrogen Receptor/ERR Aldose Reductase
3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC₅₀=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm .

HY-N15362

5α-Pregnane-3β,17α,20α-triol	Animals Steroids Source Classification	Endogenous Metabolite
5α-Pregnane-3β,17α,20α-triol is an endogenous steroid compound. 5α-Pregnane-3β,17α,20α-triol is the metabolite of Pregnenolone (HY-B0151) or Progesterone (HY-N0437). 5α-Pregnane-3β,17α,20α-triol is promising for research of the endocrine function of the placenta and the mechanisms related to steroid hormone metabolism during pregnancy .

Cat. No.	Compare	Nombre del producto	Species	Source	Image

HY-P705640

	PAQR7 Protein, Human (Cell-Free, His) mPR alpha; Membrane progesterone P4 receptor alpha; Membrane progesterone receptor alpha; progesterone and adipoQ receptor family member 7; Progestin and adipoQ receptor family member 7; Progestin and adipoQ receptor family member VII	Human	E. coli Cell-free

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Cat. No.	Nombre del producto	Chemical Structure

HY-N0437S

Progesterone-d9
Progesterone-d₉ is the deuterium labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-111614S2

Melengestrol acetate-d3

Melengestrol acetate-d₃ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity . Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research .

HY-107850S

Pregnanediol-d5
Pregnanediol-d₅ is the deuterium labeled Pregnanediol. Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo .

HY-N0437S2

Progesterone-13C3 1 Publications Verification
Progesterone- ¹³C₃ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-B0469S

Medroxyprogesterone acetate-d3 1 Publications Verification
Medroxyprogesterone acetate-d₃ is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-B0257AS

Dydrogesterone-D6
Dydrogesterone-d₆ is the deuterium labeled Dydrogesterone. Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.

HY-13683S

Mifepristone-d3
Mifepristone-d₃ is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay .

HY-W006492S

5a-Pregnane-3,20-dione-d6
5a-Pregnane-3,20-dione-d₆ is the deuterium labeled 5a-Pregnane-3,20-dione. 5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-B0084S2

Dienogest-d6
Dienogest-d₆ is deuterium labeled Dienogest (HY-B0084). Dienogest is an orally active progesterone receptor agonist that can be used in the study of endometriosis ^.

HY-13683S2

Mifepristone-d6
Mifepristone-d₆ is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay .

HY-111372S

Finerenone-d3

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-111372S1

Finerenone-d5

1 Publications Verification

Finerenone-d₅ (BAY 94-8862-d₅) is deuterium labeled Finerenone. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-N0437S3

Progesterone-13C2
Progesterone- ¹³C₂ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-B0648S

Medroxyprogesterone-d3
Medroxyprogesterone-d₃ is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

HY-W040047S

Pregnanediol 3-glucuronide-13C5

Pregnanediol 3-glucuronide is the main end-metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is a metabolite of Progesterone formed by hydroxylation and glucuronidation in the liver, with high hydrophilicity and easy excretion through urine. Pregnanediol 3-glucuronide excretion rate of ≥ 9 μmol/24 h can serve as biochemical evidence of ovulation. Pregnanediol 3-glucuronide reflects the quality of the luteal phase, and a level of < 7 μmol/24 h may indicate anovulation or luteal insufficiency. Pregnanediol 3-glucuronide holds significant importance in monitoring female reproductive health, assessing pregnancy, and diagnosing endocrine disorders.

HY-16508S

Ulipristal acetate-d6
Ulipristal acetate-d₆ is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma .

HY-B0251S

Eplerenone-d3
Eplerenone-d₃ is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC₅₀ of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch .

HY-B0652S1

Etonogestrel-d6
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-13676S

Megestrol acetate-d3

Megestrol acetate-d₃ is the deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .

HY-N0437S1

Progesterone-13C5
Progesterone- ¹³C₅ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-14959S

Ulipristal-d3
Ulipristal-d₃ (CDB-3236-d₃) is deuterium labeled Ulipristal. Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system .

HY-B0111RS

Drospirenone-13C3
Drospirenone- ¹³C₃ is ¹³C labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progesterone that is an analog of Spironolactone .

HY-B1834S1

Megestrol-d5
Megestrol-d₅ is the deuterium labeled Megestrol. Megestrol is an orally active *glucocorticoid and progesterone* receptor** agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause glucocorticoid-like effects and an increased risk of mental disorders.

HY-14281S

Trilostane-d3
Trilostane-d₃ is the deuterium-labeled Trilostane (HY-14281). Trilostane-d₃ (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane-d₃ is a synthetic nonhormonal steroid. Trilostane-d₃ can be used for the research of breast cancer and prostate cancer .

HY-13676S1

Megestrol acetate-d3-1

Megestrol acetate-d₃-1 is deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .

HY-16508S1

Ulipristal acetate-d3
Ulipristal acetate-d₃ (CDB-2914-d₃) is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma .

HY-109171S

Elinzanetant-d3
Elinzanetant-d₃ (NT-814-d₃) is deuterium labeled Elinzanetant. Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women .

HY-W743417

(-)-Norgestrel-d6
(-)-Norgestrel-d₆ is the deuterium labeled Levonorgestrel (HY-B0257). Levonorgestrel is an orally active inhibitor of progesterone (HY-N0437). Levonorgestrel has anticancer activity and can induce Apoptosis. Levonorgestrel can be used as a contraceptive and in combination with other medications. Levonorgestrel can be used in the study of osteoporosis and uterine leiomyoma .

HY-139244S

Norgestimate-d6

Norgestimate-d₆ is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive . Norgestimate-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111614S

Melengestrol acetate-d6

Melengestrol acetate-d₆ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity . Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research .

HY-111614S1

Melengestrol acetate-d2

Melengestrol acetate-d₂ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity . Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research .

HY-13683S1

Mifepristone-13C,d3

Mifepristone- ¹³C,d₃ is the ¹³C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay . Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1095S1

Chlormadinone acetate-d6-1

Chlormadinone acetate-d₆-1 is deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-B1095S2

Chlormadinone acetate-d3

Chlormadinone acetate-d₃ is the deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-106827S1

Trimegestone-13C,d3

Trimegestone- ¹³C,d₃ is ¹³C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC₅₀ value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC₅₀=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .

HY-12516S2

Desogestrel-13C2,d2-1

Desogestrel- ¹³C₂,d₂-1 (Org-2969- ¹³C₂,d₂-1) is the deuterium labeled and ¹³C-labeled Desogestrel (HY-12516). Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-B0742S1

Hydroxyprogesterone caproate-d8

Hydroxyprogesterone caproate-d₈ (17α-Hydroxyprogesterone hexanoate-d₈) is the deuterium labeled Hydroxyprogesterone caproate (HY-B0742). Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

HY-B0469S1

Medroxyprogesterone acetate-d7
Medroxyprogesterone acetate-d₇ (Medroxyprogesterone 17-acetate-d₇) is the deuterium labeled Medroxyprogesterone acetate (HY-B0469) . Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-W950003

(Rac)-Finerenone-d5

(Rac)-Finerenone-d₅ ((Rac)-BAY 94-8862-d₅) is the deuterium labeled (Rac)-Finerenone (HY-111372A). (Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold).

Host:	Mouse (6) Rabbit (6)
Reactivity:	Human (12) Bovine (1) Rat (4) Mouse (6) Rabbit (1) Dog (1) Pig (1)
Application:	IHC-P (10) ICC/IF (8) IP (5) IHC-F (1) WB (10) FC (5) ELISA (3)
Isotype:	IgG (6) IgG1 (4) IgG1,IgG/Kappa (1)
Conjugation:	Non-conjugated (12)
Clonality:	Monoclonal (7) Monoclonal Antibody (1) Recombinant (4)
Modification:	Phosphorylated (1) Unmodified (7)

Cat. No.	Compare	Nombre del producto	Application	Reactivity	Image

HY-P85965

	Progesterone Receptor Antibody (YA5657) progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3;	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat, Rabbit
	Progesterone Receptor Antibody (YA5657) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Progesterone Receptor.

HY-P87283

	PGRMC1 Antibody (YA6966) HPR6.6 antibody; Membrane associated progesterone receptor component 1 antibody; Membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; PGRMC antibody; Pgrmc1 antibody; progesterone binding protein antibody; progesterone receptor membrane component 1 antibody	IHC-P, ICC/IF, FC	Human
	PGRMC1 Antibody (YA6966) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGRMC1.

HY-P87283A

	PGRMC1 Antibody (YA6966)(PBS only) HPR6.6 antibody; Membrane associated progesterone receptor component 1 antibody; Membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; PGRMC antibody; Pgrmc1 antibody; progesterone binding protein antibody; progesterone receptor membrane component 1 antibody	IHC-P, ICC/IF, FC	Human
	PGRMC1 Antibody (YA6966) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGRMC1.

HY-P82121

	Progesterone Receptor Antibody (YA1866) PGR; NR3C3; progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3	WB, IHC-P, ICC/IF, IP	Human
	Progesterone Receptor Antibody (YA1866) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Progesterone Receptor.

HY-P83972

	Progesterone Receptor Antibody (YA3669) PR; NR3C3	WB, IHC-P, FC, ELISA	Human, Mouse
	Progesterone Receptor Antibody (YA3669) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Progesterone Receptor.

HY-P81991

	*Phospho-Progesterone* Receptor (Ser190) Antibody (YA1736)** PGR; NR3C3; progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3	WB, IHC-P	Human
	Phospho-Progesterone Receptor (Ser190) Antibody (YA1736) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Progesterone Receptor (Ser190).

HY-P83972A

	Progesterone Receptor Antibody (YA3669)(PBS only) PR; NR3C3	WB, IHC-P, FC, ELISA	Human, Mouse
	Progesterone Receptor Antibody (YA3669) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Progesterone Receptor.

HY-P81991A

	*Phospho-Progesterone* Receptor (Ser190) Antibody (YA1736)(PBS only)** PGR; NR3C3; progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Phospho-Progesterone Receptor (Ser190) Antibody (YA1736) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Progesterone Receptor (Ser190).

HY-P83386

	p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p23.

HY-P83386A

	p23 Antibody (YA3131)(PBS only) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p23.

HY-P87041

	Phosphoserine aminotransferase Antibody (YA6734) EC 2.6.1.52 antibody; Endometrial progesterone induced protein antibody; EP; IP : antibody; MGC1460 antibody; NLS2 antibody; Phosphohydroxythreonine aminotransferase antibody; phosphoserine aminotransferase 1 antibody; Phosphoserine aminotransferase antibody; PSA antibody; PSAT antibody; EC 2.6.1.52 antibody; Endometrial progesterone induced protein antibody; EP; IP : antibody; MGC1460 antibody; NLS2 antibody; Phosphohydroxythreonine aminotransferase antibody; phosphoserine aminotransferase 1 antibody; Phosphoserine aminotransferase antibody; PSA antibody; PSAT antibody; Psat1 antibody; PSATD antibody; SERC_HUMAN antibody;	WB, IHC-P, FC, IP	Human, Mouse, Rat
	Phosphoserine aminotransferase Antibody (YA6734) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phosphoserine aminotransferase.

HY-P85433

	Hsc70 Interacting Protein Antibody (YA5125) ST13; AAG2; FAM10A1; HIP; SNC6; Hsc70-interacting protein; Hip; Aging-associated protein 2; progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tum	WB, IHC-P, ICC/IF	Human, Bovine, Dog, Pig
	Hsc70 Interacting Protein Antibody (YA5125) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsc70 Interacting Protein.

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Cat. No.	Nombre del producto		Classification

HY-B0257

Levonorgestrel 2 Publications Verification D-Norgestrel		Alkynes
Levonorgestrel is an orally active inhibitor of *progesterone* (HY-N0437). Levonorgestrel has anticancer activity and can induce Apoptosis. Levonorgestrel can be used as a contraceptive and in combination with other medications. Levonorgestrel can be used in the study of osteoporosis and uterine leiomyoma .

HY-12516

Desogestrel 1 Publications Verification Org-2969		Alkynes
Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-N7137

Norgestrel 1 Publications Verification		Alkynes
Norgestrel is a synthetic analog of progesterone, a compound commonly found in oral contraceptive pill, and a powerful neuroprotective antioxidant, preventing light-induced ROS in photoreceptor cells, and cell death . Norgestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W013172

Norgestimate		Alkynes
Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive . Norgestimate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139659

ARD-61		PROTAC Synthesis
ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice . ARD-61 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1012

Quinestrol W-3566		Alkynes
Quinestrol (W-3566) is an orally effective synthetic estrogen compound that acts on CYP3A4, CYP1A2, and GnRH. Quinestrol interferes with GnRH release and disrupts the hypothalamic-pituitary-ovarian axis. Quinestrol downregulates the gene expression of follicle-stimulating hormone β and luteinizing hormone β, induces oxidative stress, damages reproductive organs, reduces sperm density and motility, increases sperm malformation rate, and alters the levels of sex hormones such as testosterone, luteinizing hormone, estradiol, and progesterone. Quinestrol can be used in studies related to reproductive function regulation .

HY-111302

Norgestrienone		Alkynes
Norgestrienone is a progestin receptor agonist. Norgestrienone is commonly used as a progesterone compound in birth control pills and can be combined with ethinylestradiol. Norgestrienone is a click chemical. It contains Alkyne groups and can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Azide groups. Norgestrienone can be used in the study of hereditary angioneurotic edema .

HY-123420

Dinordrin Dinordrin I		Alkynes
Dinordrin (Dinordrin I) is a steroid with a luteolytic effect. Dinordrin can cause depression of both plasma estrogen and progesterone levels .

HY-139244S

Norgestimate-d6		Alkynes
Norgestimate-d₆ is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive . Norgestimate-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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