2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Cloprostenol

Cloprostenol is a prostaglandin F-2α (PGF2α (HY-12956)) analogue. Cloprostenol induces luteolysis in marmoset monkeys. Cloprostenol can be used for the research of open-cervix pyometra.

For research use only. We do not sell to patients.

Cloprostenol

Cloprostenol Chemical Structure

CAS No. : 40665-92-7

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Other Forms of Cloprostenol:

Cloprostenol Related Antibodies

Top Publications Citing Use of Products

View All Prostaglandin Receptor Isoform Specific Products:

View All Isoforms
DP EP FP IP TXA2/TP TXB2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cloprostenol is a prostaglandin F-2α (PGF2α (HY-12956)) analogue. Cloprostenol induces luteolysis in marmoset monkeys. Cloprostenol can be used for the research of open-cervix pyometra[1][2].

In Vivo

Cloprostenol (0.5 μg; i.m.; single injection) induces luteolysis in non-pregnant and pregnant marmoset marmoset monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Female Common marmoset monkeys (250-510 g, regular ovarian cycles)[1]
Dosage: 0.5 μg
Administration: i.m.; single injection
Result: Failed to induce luteolysis in animals treated on Days 6 or 7 of the ovarian cycle, with progesterone concentrations remaining elevated until at least Day 15-16 post-injection.
Induced luteolysis in 3/5 animals treated on Day 8.
Induced luteolysis in 1/2 animals treated on Day 9.
Induced complete, irreversible luteolysis within 24 hours in all 23 animals treated between Days 10 and 17, with progesterone falling to <10 ng/mL and remaining at this level until the day after post-treatment ovulation.
Resulted in a mean interval from injection to ovulation of 10.7 days for treatments between Days 8 and 17 where permanent luteolysis occurred, with no significant difference between mid-luteal and late luteal phase treatments, or between females paired with vasectomized versus intact males.
Produced post-treatment ovarian cycles with a normal mean length of 27.6 days and luteal phase of 18.7 days in 7 animals monitored.
Animal Model: Adult Female Common marmoset monkeys (range 250-510 g, pregnant between Days 19 and 43)[1]
Dosage: 0.5 μg
Administration: i.m.; single injection
Result: Induced complete luteolysis within 24 hours in all 7 pregnant animals, with progesterone falling to <10 ng/mL and remaining at this level until the day after post-treatment ovulation.
Resulted in a mean interval from injection to ovulation of 10.9 days.
Produced 23 morphologically normal embryos out of 24 collected 6-9 days post-treatment from 11 animals, with 1 degenerate morula.
Molecular Weight

424.92

Formula

C22H29ClO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CCC/C=C\C[C@H]1[C@@H]([C@@H](O)C[C@H]1O)/C=C/[C@H](O)COC2=CC(Cl)=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Cloprostenol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cloprostenol40665-92-7Prostaglandin Receptorprostaglandin F-2αprogesteronecorpus luteummarmoset monkeysovarian cycleopen-cervix pyometraluteal phaseembryosqueensovulationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Cloprostenol
Cat. No.:
HY-121314
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (392 KB) Français - FR (392 KB) Deutsch - DE (392 KB) Norwegian - NO (392 KB) Español - ES (392 KB) Swedish - SV (392 KB) Italian - IT (392 KB) Korean - KR (392 KB) Portuguese - PT (392 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.