Desogestrel-13C2,d2-1
Desogestrel-13C2,d2-1 (Org-2969-13C2,d2-1) is the deuterium labeled and 13C-labeled Desogestrel (HY-12516). Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Formula: C2013C2H28D2O
- Molecular Weight:314.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 54024-22-5
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Molecular Weight 314.47
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Formula C2013C2H28D2O
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SMILES
[H][C@@]12C(CC[C@]([H])([C@@]23[H])[C@@]([H])([C@@]4(CC3=C)CC)CC([2H])([C@@]4(O)[13C]#[13CH])[2H])=CCCC1
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Synonyms
Org-2969-13C2,d2-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Rosenberg MJ, et al. The effect of desogestrel, gestodene, and other factors on spotting and bleeding. Contraception. 1996 Feb;53(2):85-90. [Content Brief]
[2]. Barkfeldt J, et al. The effects of two progestogen-only pills containing either desogestrel (75 microg/day) or levonorgestrel (30 microg/day) on lipid metabolism. Contraception. 2001 Nov;64(5):295-9. [Content Brief]
[3]. Grandi G, et al. Pharmacokinetic evaluation of desogestrel as a female contraceptive. Expert Opin Drug Metab Toxicol. 2014 Jan;10(1):1-10. [Content Brief]
[4]. Cardani S, et al., Desogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells. Exp Cell Res. 2018 Sep 15;370(2):671-679. [Content Brief]
[5]. Xie H, et al., Effect of progestin on thyroid function in female Wistar rats. Front Endocrinol (Lausanne). 2024 Jun 5;15:1362774. [Content Brief]
[6]. Gassen DT, et al. Evaluation of hormonal suppression with two contraceptive regimens using ethinyl estradiol and desogestrel. Arch Gynecol Obstet. 2013 Feb;287(2):289-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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