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  2. Androgen Receptor
  3. PF-998425

PF-998425 

Cat. No.: HY-14250 Purity: ≥98.0%
Handling Instructions

PF-998425 is a potent, selective nonsteroidal androgen receptor (AR) antagonist with an IC50 of 37 nM and 43 nM in AR binding and cellular assays, respectively. PF-998425 has low activity on common receptors and enzymes, such as progesterone receptor. PF-998425 can be used for sebum control and androgenetic alopecia research.

For research use only. We do not sell to patients.

PF-998425 Chemical Structure

PF-998425 Chemical Structure

CAS No. : 1076225-27-8

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Description

PF-998425 is a potent, selective nonsteroidal androgen receptor (AR) antagonist with an IC50 of 37 nM and 43 nM in AR binding and cellular assays, respectively. PF-998425 has low activity on common receptors and enzymes, such as progesterone receptor. PF-998425 can be used for sebum control and androgenetic alopecia research[1].

IC50 & Target

IC50: 37 nM (AR binding) and 43 nM (AR cellular)[1]

In Vivo

PF-998425 (Compound (-)-6a) is rapidly metabolized in rat liver microsomes (t1/2=4 min, CLint=350 (µL/min)/mg protein). In vivo clearance data in dogs are consistent with the high clearance predicted in vitro in rat. Following intravenous administration of PF-998425, mean systemic plasma clearance is 40 (mL/min)/kg. The mean apparent of volume of distribution at steady state is 6.5 L/kg, and the mean terminal phase half-life is 2.6 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

269.26

Formula

C₁₄H₁₄F₃NO

CAS No.

1076225-27-8

SMILES

O[[email protected]]1[[email protected]](CCCC1)C2=CC(C(F)(F)F)=C(C=C2)C#N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥98.0%

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Keywords:

PF-998425PF998425PF 998425Androgen ReceptornonsteroidalsebumandrogeneticalopeciaInhibitorinhibitorinhibit

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PF-998425
Cat. No.:
HY-14250
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