NSC-88915
NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative.
For research use only. We do not sell to patients.
- CAS No.: 21170-34-3
- Formula: C27H33BrO5S
- Molecular Weight:549.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 21170-34-3
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Molecular Weight 549.52
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Formula C27H33BrO5S
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SMILES
O=S(C1=CC=C(C=C1)Br)(OCC([C@H]2CC[C@]3([C@@]4(CCC5=CC(CC[C@@]5([C@]4(CC[C@]23C)[H])C)=O)[H])[H])=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Dexheimer, T. S., et al., (2009). 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Journal of medicinal chemistry, 52(22), 7122-7131. [Content Brief]
[2]. Nguyen, T. X., et al., (2012). Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. Journal of medicinal chemistry, 55(9), 4457-4478. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NSC-88915 Related Classifications
HY-124486 Related Classifications
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