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Cat. No.: HY-N3493

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Isocupressic acid

(Synonyms: (+)-Isocupressic acid)

Isocupressic acid ((+)-Isocupressic acid) is an abortifacient compound.

For research use only. We do not sell to patients.

CAS No.: 1909-91-7
Formula: C₂₀H₃₂O₃
Molecular Weight:320.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Isocupressic acid Chemical Structure

CAS No.: 1909-91-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Isocupressic acid ((+)-Isocupressic acid) is an abortifacient compound^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>40 μM Compound: 17	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23691952]
HL-60	IC₅₀	>40 μM Compound: 17	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23691952]
HT-1080	ED₅₀	72.91 μg/mL Compound: 10	Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay	[PMID: 9677271]
MCF7	IC₅₀	>40 μM Compound: 17	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23691952]
Neutrophil	IC₅₀	4.8 μM Compound: 6	Anti-inflammatory activity against human neutrophils assessed as inhibition of fMLF/CB-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins and measured after 10 mins by spectrophotometric Anti-inflammatory activity against human neutrophils assessed as inhibition of fMLF/CB-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins and measured after 10 mins by spectrophotometric	[PMID: 32223924]
SMMC-7721	IC₅₀	>40 μM Compound: 17	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 23691952]
SW480	IC₅₀	>40 μM Compound: 17	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 23691952]

In Vitro

Isocupressic acid (1-1000 ng/mL; 4 h) inhibits basal and ovine luteinizing hormone (oLH) stimulating secretion of progesterone in bovine luteal cells without cell death^[1].
Isocupressic acid inhibits progesterone production by blocking oLH and cAMP actions at the cellular level of luteal cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1909-91-7
Molecular Weight 320.47
Formula C₂₀H₃₂O₃
SMILES

C[C@@]1([C@H]2CC/C(C)=C/CO)[C@](CCC2=C)([H])[C@](C)(CCC1)C(O)=O
Synonyms

(+)-Isocupressic acid
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu LS, et al. Isocupressic acid blocks progesterone production from bovine luteal cells. Am J Chin Med. 2002;30(4):533-41. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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