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Promegestone (Synonyms: R-5020; Surgestone)

Cat. No.: HY-119384
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Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research.

For research use only. We do not sell to patients.

Promegestone Chemical Structure

Promegestone Chemical Structure

CAS No. : 34184-77-5

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Description

Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research[1].

In Vitro

Promegestone (R-5020; 1 nM) is efficient ligand with a full agonist response profile and a low EC50 of 0.33 nM) in HELN-hPR while it only partially induced luciferase activity in U2OS-zfPR (EC50=1.93 nM)[1].
Promegestone is inactive in HELN cells that express luciferase but no functional receptor[1].
Promegestone (10 nM) robustly stimulates SLC37A2 expression in cells expressing SUMO-deficient PR, but not in cells expressing WT PR in T47D cell models[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice on day 18 postbreeding has the least deterioration in extracellular collagen (lowest OD) and highest cell density compared to other groups on the day before birth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

326.47

Formula

C₂₂H₃₀O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Promegestone
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