PGRMC1 Antibody (YA6966)(PBS only)
(Synonyms: HPR6.6 antibody; Membrane associated progesterone receptor component 1 antibody; Membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; PGRMC antibody; Pgrmc1 antibody; Progesterone binding protein antibody; Progesterone receptor membrane component 1 antibody)PGRMC1 Antibody (YA6966) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGRMC1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
PGRMC1 Antibody (YA6966) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGRMC1.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 21.7kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 21.7kDa
Purified recombinant fragment of human PGRMC1 (AA: 1-195) expressed in E. Coli.
Protein A affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PGRMC1 component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization[1][2][3][4].
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Subcellular Localization
Microsome membrane,Smooth endoplasmic reticulum membrane,Mitochondrion outer membrane,Secreted
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Expression
Tissue_Specificity: Detected in urine (at protein level) (PubMed:36213313, PubMed:37453717). Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Widely expressed, with highest expression in liver and kidney -
Isoforms & Post-Translational Modification
O00264 has two isomers: O00264-1: 21671 Da (predicted); O00264-2: 15879 Da (predicted).
O-glycosylated; contains chondroitin sulfate attached to Ser-54 -
Subunit
Homodimer
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SwissProt ID
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Synonyms
HPR6.6 antibody; Membrane associated progesterone receptor component 1 antibody; Membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; PGRMC antibody; Pgrmc1 antibody; Progesterone binding protein antibody; Progesterone receptor membrane component 1 antibody
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