Aglepristone
Based on 1 Customer Validation
Aglepristone is a synthetic steroidal antiprogestin with abortifacient activity. Aglepristone is used exclusively as an abortifacient in pregnant animals. Aglepristone has been shown to be a safe and effective abortifacient in the second trimester of pregnancy. Aglepristone causes termination of pregnancy and does not cause fetal resorption. During aglepristone treatment, an increase in plasma concentrations of prolactin was observed, while progesterone levels remained unchanged. The use of aglepristone also resulted in early arrest of corpus luteum function and a shortening of the estrus interval.
For research use only. We do not sell to patients.
- Purity: 97.24%
- CAS No.: 124478-60-0
- Formula: C29H37NO2
- Molecular Weight:431.61
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Chemical Information
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CAS No. 124478-60-0
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Appearance Solid
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Molecular Weight 431.61
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Formula C29H37NO2
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Color Off-white to light yellow
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SMILES
C[C@@]12[C@](CC[C@@]2(O)/C=C\C)([H])[C@@]3([H])C([C@@H](C4=CC=C(C=C4)N(C)C)C1)=C5C(CC3)=CC(CC5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (231.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3169 mL | 11.5845 mL | 23.1691 mL | 57.9227 mL |
| 5 mM | 0.4634 mL | 2.3169 mL | 4.6338 mL | 11.5845 mL | |
| 10 mM | 0.2317 mL | 1.1585 mL | 2.3169 mL | 5.7923 mL | |
| 15 mM | 0.1545 mL | 0.7723 mL | 1.5446 mL | 3.8615 mL | |
| 20 mM | 0.1158 mL | 0.5792 mL | 1.1585 mL | 2.8961 mL | |
| 25 mM | 0.0927 mL | 0.4634 mL | 0.9268 mL | 2.3169 mL | |
| 30 mM | 0.0772 mL | 0.3862 mL | 0.7723 mL | 1.9308 mL | |
| 40 mM | 0.0579 mL | 0.2896 mL | 0.5792 mL | 1.4481 mL | |
| 50 mM | 0.0463 mL | 0.2317 mL | 0.4634 mL | 1.1585 mL | |
| 60 mM | 0.0386 mL | 0.1931 mL | 0.3862 mL | 0.9654 mL | |
| 80 mM | 0.0290 mL | 0.1448 mL | 0.2896 mL | 0.7240 mL | |
| 100 mM | 0.0232 mL | 0.1158 mL | 0.2317 mL | 0.5792 mL |
Aglepristone Related Classifications
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