PGRMC1 Antibody (YA6966)

Cat. No.: HY-P87283: Data Sheet User Guide for Antibodies
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PGRMC1 Antibody (YA6966) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGRMC1.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

PGRMC1 Antibody (YA6966) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGRMC1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 21.7kDa;

Observed band size: 21.7kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

O00264

Immunogen

Purified recombinant fragment of human PGRMC1 (AA: 1-195) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Sensitivity	Endogenous	Purity	Protein A affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021)

Subcellular Localization：Microsome membrane,Smooth endoplasmic reticulum membrane,Mitochondrion outer membrane,Secreted

Expression：
Tissue_Specificity: Detected in urine (at protein level) (PubMed:36213313, PubMed:37453717). Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Widely expressed, with highest expression in liver and kidney

Isoforms & Post-Translational Modification：O00264 has two isomers: O00264-1: 21671 Da (predicted); O00264-2: 15879 Da (predicted).
O-glycosylated; contains chondroitin sulfate attached to Ser-54

Subunit：Homodimer

Synonyms

HPR6.6 antibody; Membrane associated progesterone receptor component 1 antibody; Membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; PGRMC antibody; Pgrmc1 antibody; Progesterone binding protein antibody; Progesterone receptor membrane component 1 antibody

Documentation

User Guide for Antibodies (1077 KB)