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製品番号: HY-116968

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JVW-1009

JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R K_i = 96 nM; Sig2R K_i = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2089059-30-1
分子式: C₂₄H₂₄N₂
分子量:340.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

JVW-1009 構造式

CAS 番号: 2089059-30-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R K_i = 96 nM; Sig2R K_i = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease^[1].

IC₅₀ & Target^[1]

Sigma 1 Receptor

96 nM (Ki)

Sigma 2 Receptor

70 nM (Ki)

Sigma Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

JVW-1009 binds to purified Sig1R (K_i = 96 nM) and Sig2R (K_i = 70 nM) with approximately equivalent affinity^[1].
JVW-1009 (200 μM; 5-day) significantly reduces age-dependent neurodegeneration of VC4 and VC5 cholinergic neurons in SC_APP *Caenorhabditis elegans* via a PGRMC1-mediated pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2089059-30-1
分子量 340.47
分子式 C₂₄H₂₄N₂
SMILES

C(N1[C@]2(C=3C([C@@](C2)(CC1)[H])=CC=C(NC4=CC=CC=C4)C3)[H])C5=CC=CC=C5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Yi B, et al. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017;140(4):561-575. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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