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Cat. No.: HY-116968

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JVW-1009

JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R K_i = 96 nM; Sig2R K_i = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 2089059-30-1
Formula: C₂₄H₂₄N₂
Molecular Weight:340.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JVW-1009 Chemical Structure

CAS No.: 2089059-30-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R K_i = 96 nM; Sig2R K_i = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease^[1].

IC₅₀ & Target

^[1]

Sigma 1 Receptor

96 nM (Ki)

Sigma 2 Receptor

70 nM (Ki)

All Sigma Receptor Isoforms :

In Vitro

JVW-1009 binds to purified Sig1R (K_i = 96 nM) and Sig2R (K_i = 70 nM) with approximately equivalent affinity^[1].
JVW-1009 (200 μM; 5-day) significantly reduces age-dependent neurodegeneration of VC4 and VC5 cholinergic neurons in SC_APP *Caenorhabditis elegans* via a PGRMC1-mediated pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2089059-30-1
Molecular Weight 340.47
Formula C₂₄H₂₄N₂
SMILES

C(N1[C@]2(C=3C([C@@](C2)(CC1)[H])=CC=C(NC4=CC=CC=C4)C3)[H])C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yi B, et al. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017;140(4):561-575. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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