2. Neuronal Signaling
  3. Sigma Receptor
  4. JVW-1009

JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R Ki = 96 nM; Sig2R Ki = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease.

For research use only. We do not sell to patients.

JVW-1009

JVW-1009 Chemical Structure

CAS No. : 2089059-30-1

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JVW-1009 Related Antibodies

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Description

JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R Ki = 96 nM; Sig2R Ki = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease[1].

IC50 & Target[1]

Sigma 1 Receptor

96 nM (Ki)

Sigma 2 Receptor

70 nM (Ki)

In Vitro

JVW-1009 binds to purified Sig1R (Ki = 96 nM) and Sig2R (Ki = 70 nM) with approximately equivalent affinity[1].
JVW-1009 (200 μM; 5-day) significantly reduces age-dependent neurodegeneration of VC4 and VC5 cholinergic neurons in SC_APP *Caenorhabditis elegans* via a PGRMC1-mediated pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JVW-1009 Related Antibodies
Molecular Weight

340.47

Formula

C24H24N2
CAS No.
SMILES

C(N1[C@]2(C=3C([C@@](C2)(CC1)[H])=CC=C(NC4=CC=CC=C4)C3)[H])C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JVW-1009 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JVW-10092089059-30-1JVW1009JVW 1009Sigma Receptortransgenic C. elegans modelhuman Sig1Rsigma 2 receptorprogesterone receptor membrane component-1alzheimer’s diseaseVC4 cholinergic neuronsSC_APP *C. elegans*VC5 cholinergic neuronsneurodegenerationInhibitorinhibitorinhibit

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