2. Vitamin D Related/Nuclear Receptor
  3. Progesterone Receptor
  4. WAY-255348

W-255348 is an effective non-steroidal progesterone receptor (PR) antagonist that acquires antagonist activity by binding to and subsequently blocking progesterone induced nuclear accumulation, phosphorylation, and PR promoter interactions. WAY-255348 can be used in the research of reproductive disorders or PR-positive breast cancer.

For research use only. We do not sell to patients.

WAY-255348

WAY-255348 Chemical Structure

CAS No. : 872141-23-6

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WAY-255348 Related Antibodies

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Description

W-255348 is an effective non-steroidal progesterone receptor (PR) antagonist that acquires antagonist activity by binding to and subsequently blocking progesterone induced nuclear accumulation, phosphorylation, and PR promoter interactions. WAY-255348 can be used in the research of reproductive disorders or PR-positive breast cancer[1].

Cellular Effect
Cell Line Type Value Description References
COS-7 IC50
196 nM
Compound: 27, WAY-255348
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4 hybrid assay
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4 hybrid assay
[PMID: 18318463]
COS-7 IC50
3700 nM
Compound: 27, WAY-255348
Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assay
Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assay
[PMID: 18318463]
T47D IC50
4.1 nM
Compound: 27, WAY-255348
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay
[PMID: 18318463]
T47D IC50
5 nM
Compound: 27, WAY-255348
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase
[PMID: 18318463]
Molecular Weight

283.30

Formula

C16H14FN3O
CAS No.
SMILES

N#CC1=CC=C(N1C)C2=CC3=C(NC(C3(C)C)=O)C(F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WAY-255348 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-255348872141-23-6WAY255348WAY 255348Progesterone ReceptorNR3C3AntagonistPR-positive breast cancerInhibitorinhibitorinhibit

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WAY-255348
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HY-12073
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